POPE MOSELEY, MD
Osteopathic Medicine in Albuquerque, NM

6713608, Mar 30, 2004

Jun 20, 2002

10/176418

Erik S. Wallen - Albuquerque NM
Jan Roigas - Berlin, DE
Pope L. Moseley - Albuquerque NM

Science Technology Corporation UNM - Albuquerque NM

C07K 100

530350, 530402, 530412, 530413

A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so product is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in all elution product.

6433141, Aug 13, 2002

Mar 24, 2000

09/534381

Erik S. Wallen - Albuquerque NM
Jan Roigas - Berlin, DE
Pope L. Moseley - Albuquerque NM

University of New Mexico - Albuquerque NM

C07K 100

530350, 530402, 530412, 530413

A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution protein. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.

6455493, Sep 24, 2002

Mar 25, 1999

09/276468

Erik Wallen - Albuquerque NM
Pope L. Moseley - Albuquerque NM

University of New Mexico - Albuquerque NM

A01N 3718

514 2, 530350, 530827, 4241931, 4241841

The present invention provides a heat shock protein immunotoxin comprising: at least a fragment of a heat shock protein, the fragment being capable of being bound by an immune cell; and a toxin bound to the fragment. The present invention also provides a method for decreasing the number of immune cells in an individual using the heat shock protein immunotoxins of the present invention. In addition, the present invention provides a method for decreasing the number of immune cells in an organ using the heat shock protein immunotoxins of the present invention.

6066716, May 23, 2000

Sep 19, 1997

8/934139

Erik S. Wallen - Albuquerque NM
Jan Roigas - Albuquerque NM
Pope L. Moseley - Albuquerque NM

University of New Mexico - Albuquerque NM

C07K 1700

530350

A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.

5747332, May 5, 1998

Sep 20, 1996

8/717239

Erik S. Wallen - Albuquerque NM
Jan Roigas - Albuquerque NM
Pope L. Moseley - Albuquerque NM

University of New Mexico - Albuquerque NM

C07K 14435, C07K 1700, A61L 3817, G01N 3002

435272

A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.

2004014, Jul 22, 2004

Jan 9, 2004

10/754818

Erik Wallen - Albuquerque NM, US
Jan Roigas - Berlin, DE
Pope Moseley - Albuquerque NM, US

C07K001/16

530/412000

A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock, proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.

5981706, Nov 9, 1999

Dec 5, 1997

8/986234

Erik S. Wallen - Albuquerque NM
Pope L. Moseley - Albuquerque NM

University of New Mexico - Albuquerque NM

C07K 300, C07K 1700

530350

The present invention provides a method for synthesizing heat shock protein-peptide complexes comprising the steps of: adding a shock protein to a denatured protein matrix to bind the heat shock protein to the denatured protein matrix; and adding a complexing solution comprising a peptide to elute a heat shock protein-peptide complex. The present invention also provides a heat shock protein-peptide complex synthesized by the method of the invention. In addition the present invention provides an apparatus for synthesizing heat shock protein-peptide complexes comprising a heat shock protein complex bound to a denatured protein matrix.

2005023, Oct 20, 2005

Jan 31, 2005

11/047063

Pope Moseley - Albuquerque NM, US
Matthew Cotten - Munich, DE
Brian Hjelle - Albuquerque NM, US
Antonito Panganiban - Albuquerque NM, US
Peter Angeletti - Lincoln NE, US

A61K038/17, A61K048/00

514012000, 514044000

The present invention discloses a method of inhibiting heat shock protein-dependent virus replication in cells and in animals. The present invention also discloses a method of identifying compounds which inhibit heat shock protein-dependent virus replication.