Inventors:
Jogeshwar Mukherjee - Irvine CA, US
Elizabeth Head - Irvine CA, US
Crystal Wang - La Palma CA, US
Pooja C. Patel - Stockton CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 51/00, C07C 255/09, A61P 25/00, C07C 49/248
Abstract:
Compounds, compositions and methods are contemplated in which senile plaques and/or neurofibrillary tangles are labeled using compounds with improved permeability across the blood brain barrier and improved selective binding to senile plaques and/or neurofibrillary tangles. Contemplated compounds are derivatives of FDDNP or curcumin, which most preferably have improved solubility in aqueous solvents. Labeling is typically performed using a PET detectable label, and especially C and F.