Inventors:
Kiyoshi Ariizumi - Dallas TX, US
Ponciano D. Cruz - Dallas TX, US
International Classification:
A61K 38/21, A61K 39/395, C12N 9/00, C07K 19/00
US Classification:
424 857, 4241731, 4241781, 4241831, 435183, 5303917
Abstract:
The present invention relates to the use of DC-HIL and fragments and variants thereof to selectively target toxins to activated T-cells expressing a unique form of syndecan-4 that is not found on other cells. Thus, the toxin is delivered only to activated T-cells, and not to other syndecan-4 expressing cells. Such toxin-DC-HIL conjugates are useful in the treatment of T-cell inflammatory disorders such as dermatitis, autoimmune disease, and graft rejection, as well as T-cell lymphomas.