Inventors:
Ping H. Wang - Irvine CA, US
Lee-Ming Chuang - Taipei Hsien, TW
Arthur Lander - Laguna Beach CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
NATIONAL TAIWAN UNIVERSITY - Taipei
International Classification:
A01K 67/027, G01N 33/566, G01N 33/53, A61K 31/7088, A61P 3/10
US Classification:
800 18, 436501, 435 71, 514 44
Abstract:
The present invention provides methods, compositions, and kits useful for modulating insulin/glucose homeostasis in a subject by modulating CAP/SORBS1. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate insulin/glucose homeostasis. Methods of the invention can involve assaying test agent binding to CAP/SORBS1 polypeptides or polynucleotides. Alternatively, test agents can be screened for their ability to alter the level of CAP/SORBS1 polypeptides, polynucleotides, or action.