Inventors:
ROGER C. ADAMI - BOTHELL WA, US
STEVEN C. QUAY - SEATTLE WA, US
PHUONG NGUYEN - CAMBRIDGE MA, US
HARRY C. WANG - SAN DIEGO CA, US
DIANE E. FRANK - SEATTLE WA, US
Assignee:
MARINA BIOTECH, INC. - BOTHELL WA
International Classification:
A61K 38/10, C07C 229/26, A61K 31/197, A61K 31/225, C07C 233/36, A61K 31/16, C07K 7/08, C07K 9/00, C07D 403/14, A61K 31/4178, C07D 403/12, A61K 31/7088, A61K 31/713, A61P 31/12, A61P 19/02, A61P 35/00, A61P 1/16, A61P 31/16, C12N 5/071
US Classification:
514 37, 562564, 514563, 560169, 514547, 564153, 514616, 530327, 514 166, 514 43, 514 193, 514 215, 530324, 514 213, 530326, 5483127, 514397, 514 44 R, 514 44 A, 435325
Abstract:
Multi-arm amine compounds and compositions for enhancing intracellular, in vitro, and in vivo delivery of drug, active, and therapeutic substances including ribonucleic acids. This disclosure provides novel compounds and compositions for making and using delivery materials and carriers which increase the efficiency of delivery of biologically active and pharmacologically active molecules. Embodiments of this disclosure may further provide delivery of various therapeutic agents including nucleic acid therapeutics such as regulatory RNA, interfering RNA, and agents for RNAi, as well as other protein and peptide therapeutics. In some aspects, this disclosure provides multi-arm amine compounds and compositions which can enhance permeation of a drug substance.