Inventors:
Carla Cerami - New York NY, US
Ute Frevert - New York NY, US
Photini Sinnis - New York NY, US
Victor Nussenzweig - New York NY, US
International Classification:
A61K038/17, C07H021/04, C12N009/99, C12P021/02, C12N005/06
US Classification:
514/012000, 435/184000, 435/069200, 435/320100, 435/325000, 536/023200
Abstract:
There is provided peptide and mimetic inhibitors for the binding of a circumsporozoite polypeptide to receptors of hepatocytes from malaria-susceptible mammals. Also contemplated is a method of inhibiting the binding of a malaria sporozoites to hepatocytes susceptible to sporozoite invasion. A peptide of Region II+ of the circumsporozoite protein is also provided, as is a method of targeting the delivery of substances to hepatocytes.