Inventors:
Charles M. Perou - Carrboro NC, US
Matthew J. Ellis - St. Louis MO, US
Philip S. Bernard - Salt Lake City UT, US
Torsten O. Nielsen - North Vancouver, CA
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
British Columbia Cancer Agency Branch - Vancouver
University of Utah Research Foundation - Salt Lake City UT
Washington University - St. Louis MO
International Classification:
A61K 31/704, A61K 31/675, A61K 31/513, A61K 31/519, A61K 39/395, A61K 33/24, A61K 31/7068, A61K 31/565, A61K 38/02, A61P 35/00, G01N 33/574, C12Q 1/68, G01N 21/64, C40B 30/04, C40B 40/06, A61K 31/136
US Classification:
4241331, 514 27, 514656, 514110, 514274, 514249, 514 83, 4241421, 424649, 514 49, 514171, 514 11, 435 723, 435 611, 506 9, 506 16
Abstract:
The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including an anthracycline. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including anthracycline and administering the therapy in subjects when it is found that anthracycline is likely to be effective.