PHILIP SAMUEL SCHEIN
Medical Practice in Delaware
License number
Pennsylvania MD031354E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Rosemont, PA 19010
Rosemont, PA 19010
Personal information
See more information about PHILIP SAMUEL SCHEIN at radaris.comName
Address
Phone
971 Oad, Bryn Mawr, PA 19010
605 Old Gulph Rd, Bryn Mawr, PA 19010
Professional information
Philip Schein, Bryn Mawr PA
Work:
Univ. of Oxford
605 Old Gulph Rd, Bryn Mawr, PA 19010
605 Old Gulph Rd, Bryn Mawr, PA 19010
Suppression Of Hiv Expression By Organic Thiophosphate
US Patent:
5824664, Oct 20, 1998
Filed:
Mar 26, 1993
Appl. No.:
8/037633
Inventors:
Philip S. Schein - Bryn Mawr PA
Thea Kalebic - Bethesda MD
Thea Kalebic - Bethesda MD
Assignee:
U.S. Bioscience, Inc. - West Conshohocken PA
National Institutes of Health, The National Cancer Institute - Rockville MD
National Institutes of Health, The National Cancer Institute - Rockville MD
International Classification:
A01N 5710, A01N 5700, A61K 3166, A61K 3113
US Classification:
514143
Abstract:
Chronic HIV infection is treated by administering to a subject an organic thiophosphate alone or in combination with another anti-HIV or anti-AIDS drug. The organic thiophosphate is preferably WR 151327, a compound with antioxidant and free radical scavenging activities, or a functional derivative or analogue thereof. WR 151327 suppresses induction of HIV expression in chronically infected cells mediated by cytokines such as TNF. alpha. and GM-CSF. Pharmaceutical compositions comprising at least one organic thiophosphate in combination with one or more anti-HIV or anti-AIDS drugs are also disclosed.
Methods For The Administration Of Amifostine And Related Compounds
US Patent:
6051563, Apr 18, 2000
Filed:
Feb 12, 1997
Appl. No.:
8/798840
Inventors:
Martin Stogniew - Blue Bell PA
Philip S. Schein - Bryn Mawr PA
Philip S. Schein - Bryn Mawr PA
Assignee:
U.S. Bioscience, Inc. - West Conshohocken PA
International Classification:
A61K 3166
US Classification:
514114
Abstract:
The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
Methods For The Administration Of Amifostine And Related Compounds
US Patent:
6218377, Apr 17, 2001
Filed:
Jun 5, 2000
Appl. No.:
9/586753
Inventors:
Martin Stogniew - Blue Bell PA
Philip S. Schein - Bryn Mawr PA
Philip S. Schein - Bryn Mawr PA
Assignee:
MedImmune Oncology Inc. - West Conshohocken PA
International Classification:
A01N 5700
US Classification:
514114
Abstract:
The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
1A-7-Substituted Derivatives Of Mitomycin And Uses Thereof
US Patent:
4720543, Jan 19, 1988
Filed:
Jun 6, 1985
Appl. No.:
6/742045
Inventors:
Eugene McPherson - Forestville MD
Philip S. Schein - Bryn Mawr PA
Philip S. Schein - Bryn Mawr PA
Assignee:
Georgetown University - Washington DC
International Classification:
C07D48714, A61K 2100, A61K 3140
US Classification:
536 181
Abstract:
This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.
Mitomycin Derivatives Having Reduced Bone Marrow Toxicity, Processes For Their Preparation, And The Uses Thereof
US Patent:
5091523, Feb 25, 1992
Filed:
Dec 3, 1990
Appl. No.:
7/620853
Inventors:
Abdolhossen Talebian - Herndon VA
Dianna Green - Falls Church VA
Charles Hammer - Washington DC
Philip Schein - Bryn Mawr PA
Alem Ghiorghis - Washington DC
Robert R. Clarke - Bethesda MD
Dianna Green - Falls Church VA
Charles Hammer - Washington DC
Philip Schein - Bryn Mawr PA
Alem Ghiorghis - Washington DC
Robert R. Clarke - Bethesda MD
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 3140, A61K 2100, C07D48714
US Classification:
536 173
Abstract:
The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin derivatives of the invention.
Method For Protection From Azt Side Effects And Toxicity
US Patent:
5804571, Sep 8, 1998
Filed:
Jun 7, 1995
Appl. No.:
8/486625
Inventors:
Philip S. Schein - Bryn Mawr PA
Assignee:
U.S. Bioscience - Blue Bell PA
International Classification:
A61K 3170, A61K 3166
US Classification:
514114
Abstract:
S-. omega. (. omega. -aminoalkylamino)alkyl dihydrogen phosphorothioates or pharmaceutically acceptable derivatives thereof are useful in protecting a patient undergoing AZT treatment for AIDS and AIDS-related complex from the harmful side effects or reactions and toxicity of the AZT.
Platinum Pharmaceutical Agents
US Patent:
4946954, Aug 7, 1990
Filed:
Jan 26, 1989
Appl. No.:
7/301773
Inventors:
Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Philip S. Schein - Bryn Mawr PA
Dianna C. Green - Falls Church VA
Philip S. Schein - Bryn Mawr PA
Assignee:
Georgetown University - Washington DC
International Classification:
C07H 1500, C07H 2300
US Classification:
536121
Abstract:
Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R. sub. 1 is H or C. sub. 1 -C. sub. 4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide,
when n is O, R. sub. 1 is H or C. sub. 1 -C. sub. 4 alkyl, R is H, halogen, non-substituted C. sub. 1 -. sub. 20 alkyl, aryl, arlalkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide,
and R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, C. sub. 1. sup. -4 alkyl or R. sub. 2 and R. sub. 3 or R. sub. 2 and R. sub. 3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R. sub. 2 and R. sub.
Method For The Administration Of Amifostine And Related Compounds
US Patent:
6127351, Oct 3, 2000
Filed:
Feb 10, 1998
Appl. No.:
9/021139
Inventors:
Martin Stogniew - Blue Bell PA
Philip S. Schein - Bryn Mawr PA
Philip S. Schein - Bryn Mawr PA
Assignee:
MedImmune Oncology Inc. - West Conshohocken PA
International Classification:
A61K 3166
US Classification:
514114
Abstract:
The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.
Platinum Pharmaceuticals
US Patent:
4895935, Jan 23, 1990
Filed:
Jan 14, 1988
Appl. No.:
7/143762
Inventors:
Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Charles F. Hammer - Washington DC
Philip S. Schein - Bryn Mawr PA
Dianna C. Green - Falls Church VA
Charles F. Hammer - Washington DC
Philip S. Schein - Bryn Mawr PA
Assignee:
Georgetown University - Washington DC
International Classification:
C07H 1500, C07H 2300
US Classification:
536 171
Abstract:
Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.