PHILIP NEEDLEMAN
Pharmacy in Saint Louis, MO
License number
Pennsylvania RP024029L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
Saint Louis, MO 63132
Pennsylvania
Pennsylvania
Personal information
See more information about PHILIP NEEDLEMAN at radaris.comName
Address
Phone
Ladue, MO
1131 Olivaire Ln, Saint Louis, MO 63132
326 New Salem Dr, Saint Louis, MO 63141
47102 Delaire Landing Rd, Philadelphia, PA 19114
Professional information
Compositions Of A Cyclooxygenase-2 Selective Inhibitor And A Peroxisome Proliferator Activated Receptor Agonist For The Treatment Of Ischemic Mediated Central Nervous System Disorders
US Patent:
2005010, May 19, 2005
Filed:
May 12, 2004
Appl. No.:
10/844269
Inventors:
Philip Needleman - Creve Coeur MO, US
Mark Obukowicz - Kirkwood MO, US
Mark Obukowicz - Kirkwood MO, US
Assignee:
Pharmacia Corporation - St. Louis MO
International Classification:
A61K031/50, A61K031/425, A61K031/415, A61K031/4439, A61K031/426, A61K031/365, A61K031/18
US Classification:
514247000, 514340000, 514369000, 514406000, 514471000, 514602000, 514374000
Abstract:
The present invention provides compositions and methods for the treatment of ischemic mediated central nervous system disorders. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic mediated disorder comprising the administration to a subject of a peroxisome proliferator activated receptor agonist in combination with a cyclooxygenase-2 selective inhibitor.
Radiopharmaceutical Compositions Capable Of Localizing At Sites Of Thrombus
US Patent:
6132697, Oct 17, 2000
Filed:
Jun 5, 1997
Appl. No.:
8/870042
Inventors:
Ananthachari Srinivasan - St. Charles MO
Larry P. Feigen - Wauconda IL
Daniel Lee Flynn - Clarkson Valley MO
Jeffery Alan Zablocki - LaFayette CO
Philip Needleman - Creve Coeur MO
Michelle A. Schmidt - Belleville IL
Larry P. Feigen - Wauconda IL
Daniel Lee Flynn - Clarkson Valley MO
Jeffery Alan Zablocki - LaFayette CO
Philip Needleman - Creve Coeur MO
Michelle A. Schmidt - Belleville IL
Assignee:
G. D. Searle & Co. - Chicago IL
International Classification:
A61K 5100, A61K 3800, C07F 500
US Classification:
424 169
Abstract:
A radiopharmaceutical capable of localizing at a site of thrombus containing activated platelets within a mammalian body is provided wherein the radiopharmaceutical comprises a linear peptidomimetic containing ligand capable of specifically binding to the GPIIb/IIIa integrin receptor of platelets in the thrombus and a radionuclide covalently bound to the peptidomimetic containing ligand. The ligand compositions of the invention are provided complexed with a selected metal radionuclide to form a diagnostic or therapeutic radiopharmaceutical to image a site of thrombus or provide radiotherapy to the site of thrombus, respectively. Methods of imaging a site of thrombus in a mammalian body by administering a diagnostically effective amount of the radiopharmaceutical composition of this invention complexed with a selected diagnostic metal radionuclide and methods of providing therapy to a site of thrombus in a mammalian body by administering a therapeutically effective amount of the radiopharmaceutical composition of this invention complexed with a selected therapeutic metal radionuclide are also provided as well as kits for preparing such radiopharmaceutical compositions.
Immunological Process And Constructs For Increasing The Hdl Cholesterol Concentration By Dna Vaccination
US Patent:
2003010, May 29, 2003
Filed:
Aug 31, 1999
Appl. No.:
09/386591
Inventors:
PHILIP NEEDLEMAN - CREVE COEUR MO, US
KEVIN GLENN - MARYLAND HEIGHTS MO, US
KEVIN GLENN - MARYLAND HEIGHTS MO, US
International Classification:
A61K048/00, C07H021/04
US Classification:
514/044000, 536/023530, 536/023200
Abstract:
A process for inducing the production of antibodies that bind to cholesteryl ester transfer protein (CETP) is disclosed. That process comprises the steps of: (a) immunizing a mammal with an inoculum containing a recombinant DNA molecule that comprises a DNA sequence that contains (i) a sequence encoding a CETP immunogen that is linked to (ii) a promoter sequence that controls expression of the CETP immunogen, the recombinant DNA molecule being dissolved or dispersed in a vehicle; and (b) maintaining the immunized mammal for a time period sufficient to induce the production of antibodies that bind to CETP, and preferably lessen the transfer of cholesteryl esters from HDL where the blood of the mammal itself contains CETP. Immunogens, inocula, DNA segments, and recombinant DNA molecule vectors useful for carrying out the invention are also disclosed.
An Immunological Process For Increasing The Hdl Cholestrol Concentration
US Patent:
2003002, Feb 6, 2003
Filed:
Aug 31, 1999
Appl. No.:
09/387340
Inventors:
PHILIP NEEDLEMAN - CREVE COEUR MO, US
KEVIN GLENN - MARYLAND HEIGHTS MO, US
ELAINE KRUL - WARSON WOODS MO, US
EDWARD P. GAMSON - HIGHLAND PARK IL, US
KEVIN GLENN - MARYLAND HEIGHTS MO, US
ELAINE KRUL - WARSON WOODS MO, US
EDWARD P. GAMSON - HIGHLAND PARK IL, US
International Classification:
A61K039/00, A61K039/38
US Classification:
424/184100
Abstract:
A process for increasing the concentration of HDL cholesterol in the blood of a mammal whose blood contains cholesterol ester transfer protein (CETP) is contemplated. That process comprises the steps of: (a) immunizing the mammal with an inoculum containing a CETP immunogen that is an immunogenic polypeptide having a CETP amino acid residue sequence that is covalently bonded to an exogenous antigenic carrier polypeptide and is dissolved or dispersed in a vehicle; and (b) maintaining the immunized mammal for a time period sufficient for said immunogenic polypeptide to induce the production of antibodies that bind to CETP and lessen the transfer of cholesteryl esters from HDL. Immunogens, inocula and DNA segments useful for carrying out the invention are also disclosed.
Method Of Using Cyclooxygenase-2 Inhibitors In The Prevention Of Cardiovascular Disorders
US Patent:
2007007, Mar 29, 2007
Filed:
Mar 23, 2006
Appl. No.:
11/387554
Inventors:
Barbara Roniker - Chicago IL, US
Richard LaChapelle - Wilmette IL, US
Daniel Connolly - Ballwin MO, US
Karen Seibert - St. Louis MO, US
Philip Needleman - Creve Coeur MO, US
Richard LaChapelle - Wilmette IL, US
Daniel Connolly - Ballwin MO, US
Karen Seibert - St. Louis MO, US
Philip Needleman - Creve Coeur MO, US
International Classification:
A61K 31/50, A61K 31/4439, A61K 31/415, A61K 31/421, A61K 31/42, A61K 31/401, A61K 31/366, A61K 31/365, A61K 31/22
US Classification:
514247000, 514357000, 514406000, 514341000, 514423000, 514460000, 514471000, 514548000, 514374000, 514378000
Abstract:
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing cardiovascular disorders.
Combination Therapy For The Treatment Of Bacterial Infections
US Patent:
2003019, Oct 9, 2003
Filed:
Jan 21, 2003
Appl. No.:
10/348300
Inventors:
Philip Needleman - Creve Coeur MO, US
Barry Hafkin - Danbury CT, US
Barry Hafkin - Danbury CT, US
International Classification:
A61K038/14, A61K031/704, A61K031/496, A61K031/416, A61K031/4709, A61K031/545, A61K031/43
US Classification:
514/008000, 514/037000, 514/192000, 514/200000, 514/253080, 514/312000, 514/300000, 514/406000
Abstract:
The present invention provides compositions and methods for treating or preventing bacterial infections. The compositions and methods include the use of antibiotics and cyclooxygenase inhibitors.
Combination Therapy In The Prevention Of Cardiovascular Disorders
US Patent:
2002003, Mar 21, 2002
Filed:
Sep 6, 2001
Appl. No.:
09/946623
Inventors:
Barbara Roniker - Chicago IL, US
Richard LaChapelle - Wilmette IL, US
Daniel Connolly - Ballwin MO, US
Karen Seibert - St. Louis MO, US
Philip Needleman - Creve Coeur MO, US
Richard LaChapelle - Wilmette IL, US
Daniel Connolly - Ballwin MO, US
Karen Seibert - St. Louis MO, US
Philip Needleman - Creve Coeur MO, US
International Classification:
A61K031/18
US Classification:
514/605000
Abstract:
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing cardiovascular disorders.
Atrial Peptides
US Patent:
4557864, Dec 10, 1985
Filed:
Jul 26, 1984
Appl. No.:
6/634858
Inventors:
Philip Needleman - Olivette MO
Assignee:
Washington University - St. Louis MO
International Classification:
C07C10352
US Classification:
2601125R
Abstract:
Novel atrial peptides having useful natriuretic activity are disclosed with the following amino acid sequence:
R. sub. 1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R. sub. 2
wherein
R. sub. 1 =H, ser, ser-ser, and
R. sub. 2 =OH, ser, ser-phe-arg, ser-phe-arg-tyr,
or the physiologically acceptable salts, esters or amides thereof.
Atrial Peptide
US Patent:
4508712, Apr 2, 1985
Filed:
May 4, 1984
Appl. No.:
6/607064
Inventors:
Philip Needleman - Olivette MO
Assignee:
Washington University - St. Louis MO
International Classification:
A61K 3700, C07C10352
US Classification:
514 11
Abstract:
A novel atrial peptide having useful natriuretic, diuretic and vasodilating activity is disclosed with the following amino acid sequence: ##STR1##.
Atrial Peptides
US Patent:
4496544, Jan 29, 1985
Filed:
Jan 10, 1984
Appl. No.:
6/569684
Inventors:
Philip Needleman - Olivette MO
Assignee:
Washington University - St. Louis MO
International Classification:
A61K 3700, C07C10352
US Classification:
514 13
Abstract:
Novel atrial peptides having useful natriuretic activity are disclosed with the following amino acid sequence:
R. sub. 1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R. sub. 2
wherein
R. sub. 1 =H, ser, ser-ser, and
R. sub. 2 =OH, ser, ser-phe-arg, ser-phe-arg-tyr,
or the physiologically acceptable salts, esters or amides thereof.