Inventors:
J. Edwin Blalock - Birmingham AL, US
Uros V. Djekic - Rockville MD, US
Patricia L. Jackson - Moody AL, US
Amit Gaggar - Homewood AL, US
Brett Noerager - Birmingham AL, US
Philip J. O'Reilly - Hoover AL, US
Assignee:
THE UAB RESEARCH FOUNDATION - Birmingham AL
International Classification:
A61K 38/00, A61K 31/7088, A61K 31/7028, A61K 31/7032, A61K 31/7105, A61K 31/401, A61K 31/722, G01N 33/573, A61K 31/7034, A61P 37/06
US Classification:
514 2, 514 44 R, 514 25, 514 35, 514 44 A, 514423, 514 55, 435 74
Abstract:
Provided herein are methods for reducing or preventing neutrophilic inflammation in a subject comprising selecting a subject with or at risk for neutrophilic inflammation and administering to the subject an agent that inhibits the expression or activity of prolyl endopeptidase. Provided herein are also methods for treatment or prevention of diseases associated with neutrophilic inflammation.