Inventors:
Vernon Holers - Denver CO, US
Joshua Thurman - Greenwood Village CO, US
Stephen Tomlinson - Mount Pleasant SC, US
Philip Stahel - Denver CO, US
Assignee:
The Regents of the University of Colorado - Boulder CO
MUSC Foundation for Research Development - Charleston SC
International Classification:
A61K 39/395
Abstract:
Disclosed is the use of agents and compositions that selectively inhibit the alternative complement pathway for the inhibiting or treating physiological damage resulting from traumatic brain injury (TBI), spinal cord injury (SCI), or related conditions. Preferred reagents for use in inhibition of damage resulting from TBI or SCI include those that inhibit factor B, with anti-factor B antibodies representing a particularly preferred agent.