Inventors:
Alexander Keith Stewart - Scottsdale AZ, US
Peter Bergsagel - Scottsdale AZ, US
Rafael Fonseca - Scottsdale AZ, US
Esteban Braggio - Scottsdale AZ, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:
A61K 31/454
Abstract:
This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.