Inventors:
Harry Soroff - Northport NY, US
Marcia Simon - Stony Brook NY, US
Thomas Fallon - Saratoga Springs NY, US
Peter Fallon - Loudonville NY, US
Gabriele Hatch - Setauket NY, US
Assignee:
Research Foundation of State University of New York - Albany NY
International Classification:
A61K 38/46, A61K 38/48, A61K 38/54, A01N 37/18
US Classification:
424 9467, 424 9463, 424 941, 514 2
Abstract:
The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e. g. , burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphatidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.