Inventors:
Robert M. Strieter - Ann Arbor MI
Peter J. Polverini - Ann Arbor MI
Steven L. Kunkel - Ann Arbor MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A01N 6300
US Classification:
424 932, 4353201, 435325, 424 852, 4241991, 514 44
Abstract:
Disclosed are various discoveries concerning the angiogenic and angiostatic properties of the CXC chemokines, including the finding that the ELR motif controls the ability of these molecules to induce angiogenesis. Aspects of the invention include, for example, the identification of IP-10, MIG and certain IL-8 analogues as angiostatic agents, and their use in inhibiting angiogenesis in various systems.