PETER HARRY DOUKAS
Pharmacy in Upper Makefield, PA
License number
Pennsylvania RP026053L
Category
Pharmacy
Type
Pharmacist
Address
Address
Upper Makefield, PA 18940
Professional information
Mannich Bases Of Spirosuccinimides
US Patent:
4925841, May 15, 1990
Filed:
Jun 27, 1988
Appl. No.:
7/211958
Inventors:
Michael R. Borenstein - Philadelphia PA
Peter H. Doukas - Newtown PA
Peter H. Doukas - Newtown PA
Assignee:
Temple University of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
C07D40314, C07D 31495
US Classification:
5142355
Abstract:
Mannich bases of spirosuccinimides are provided having anticonvulsant, sedative and antileukemic activity. The compounds have the following formula wherein ring A is a saturated or unsaturated monocyclic or bicyclic carbon ring of at least five carbon atoms: ##STR1##.
2-Substituted Trimethylpyrazine Derivatives As Inhibitors Of Platelet Function
US Patent:
4978662, Dec 18, 1990
Filed:
Apr 11, 1989
Appl. No.:
7/336261
Inventors:
Mark L. Nelson - Sommerville MA
Peter H. Doukas - Newtown PA
Leon Salganicoff - Philadelphia PA
Fiore J. Ricciardi - Milwaukee WI
Peter H. Doukas - Newtown PA
Leon Salganicoff - Philadelphia PA
Fiore J. Ricciardi - Milwaukee WI
Assignee:
Temple University of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
A61K 31495, A61K 31335, C07D24112
US Classification:
5142358
Abstract:
Novel 2-substituted trimethylpyrazine derivatives of the formula: ##STR1## wherein R is alkylamino, 4-methyl-1-piperazinyl, piperidino, morpholino or 2-trimethylpyrazinepropenyl.
These novel 2-substituted trimethylpyrazine derivatives exhibit, at very low concentrations, activity as inhibitors of platelet function and as promoters of blood pressure reduction.