PETER H LEE
Hearing Instrument Specialists in Westboro, MA
License number
Massachusetts 40
Issued Date
Jul 1, 2000
Expiration Date
Apr 1, 2017
Type
Hearing Instrument Specialist
Address
Address
Westboro, MA 01581
Professional information
Aromatic Phosphonium Salts And Their Use As Labeling Reagents In Mass Spectrometry Analysis
US Patent:
2007008, Apr 19, 2007
Filed:
Apr 14, 2004
Appl. No.:
10/553307
Inventors:
John Gebler - Hopkinton MA, US
Peter Lee - Westborough MA, US
Weibin Chen - Holliston MA, US
Peter Lee - Westborough MA, US
Weibin Chen - Holliston MA, US
Assignee:
Waters Investments Limited - New Castle DE
International Classification:
G01N 24/00
US Classification:
436173000
Abstract:
This invention relates to methods and reagents for the assay, detection, quantification, location, or analysis of each of a plurality of substances of interest (“analytes”) in a sample in which each substance is labeled with a cationic triarylphosphonium group. The present invention also provides MALDI mass spectrometry techniques in which the analysis of samples containing low molecule weight analytes is not obscured by matrix components. The invention also provides labeling reagents for use in labeling analytes prior to MS analysis in which the labeled analytes have a molecular weight above the useful detection threshold of MALDI techniques. In some aspects, the invention provides methods of quantitative MS analysis of components of a sample. Methods of the present invention include sensitive techniques for desorption/ionization of molecules at the picomole, femtomole, and attomole amounts. Another benefit of the present invention is that measurement of m/Z values is not complicated by the low-mass interference that a matrix normally offers, and therefore the invention provides methods of MALDI MS analysis of low molecular weight samples as well as mixtures of high and low molecular weight samples.
Destructible Surfactants And Uses Thereof
US Patent:
2008002, Jan 31, 2008
Filed:
Jun 11, 2007
Appl. No.:
11/811696
Inventors:
Peter Lee - Westborough MA, US
Bruce Compton - Lexington MA, US
Bruce Compton - Lexington MA, US
Assignee:
Waters Investments Limited - New Castle
International Classification:
C07D 319/06, C07D 317/14
US Classification:
549372000, 549453000
Abstract:
Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group which enables the surfactant to be broken down under acidic conditions. The invention also includes methods of making anionic surfactants and methods of using anionic surfactants in a variety of applications.
Sample Concentration Maldi Plates For Maldi Mass Spectrometry
US Patent:
2005013, Jun 16, 2005
Filed:
May 24, 2002
Appl. No.:
10/479296
Inventors:
Peter Lee - Westboro MA, US
International Classification:
G01N033/53, C12M001/34, B01D059/44
US Classification:
435007100, 435287100, 250281000
Abstract:
A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) sample support plate is described. The plate comprises a top sample presentation surface and a lower surface, wherein the top sample presentation surface comprises at least one aperture for receiving a sample. The aperture extends through and between the top sample presentation surface and the bottom surface, and contains a porous material that retains and concentrates at the target spot analyte and matrix molecules contained in the sample on the surface of the aperture. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.
Ion Exchange Porous Resins For Solid Phase Extraction And Chromatography
US Patent:
7442299, Oct 28, 2008
Filed:
May 1, 2007
Appl. No.:
11/799376
Inventors:
Peter Jeng-Jong Lee - Westborough MA, US
John E. O'Gara - Ashland MA, US
John E. O'Gara - Ashland MA, US
Assignee:
Waters Investments Limited - New Castle DE
International Classification:
B01D 15/08
US Classification:
2101982, 2105021, 210635, 210656
Abstract:
Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.
Destructible Surfactants And Uses Thereof
US Patent:
8580533, Nov 12, 2013
Filed:
May 30, 2003
Appl. No.:
10/516418
Inventors:
Edouard S. P. Bouvier - Stow MA, US
Bruce J. Compton - Lexington MA, US
John C. Gebler - Hopkinton MA, US
Martin Gilar - Franklin MA, US
Ying-Qing Yu - Milford MA, US
Peter Jeng-Jong Lee - Westborough MA, US
Elizabeth K. Brown - Sutton MA, US
Bruce J. Compton - Lexington MA, US
John C. Gebler - Hopkinton MA, US
Martin Gilar - Franklin MA, US
Ying-Qing Yu - Milford MA, US
Peter Jeng-Jong Lee - Westborough MA, US
Elizabeth K. Brown - Sutton MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
C12Q 1/37, A61K 31/095
US Classification:
435 23, 204450, 514706
Abstract:
The present invention provides methods for enhancing chemical reactions of molecules, e. g. , biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e. g. , solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
Destructible Surfactants And Uses Thereof
US Patent:
2014006, Mar 6, 2014
Filed:
Nov 8, 2013
Appl. No.:
14/075637
Inventors:
Bruce J. Compton - Lexington MA, US
John C. Gebler - Hopkinton MA, US
Martin Gilar - Franklin MA, US
Ying Q. Yu - Uxbridge MA, US
Peter J. Lee - Westborough MA, US
Elizabeth K. Brown - Sutton MA, US
John C. Gebler - Hopkinton MA, US
Martin Gilar - Franklin MA, US
Ying Q. Yu - Uxbridge MA, US
Peter J. Lee - Westborough MA, US
Elizabeth K. Brown - Sutton MA, US
Assignee:
WATERS TECHNOLOGIES CORPORATION - Milford MA
International Classification:
C12Q 1/37
US Classification:
435 23
Abstract:
The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
Ion Exchange Porous Resins For Solid Phase Extraction And Chromatography
US Patent:
8574433, Nov 5, 2013
Filed:
Aug 12, 2010
Appl. No.:
12/855300
Inventors:
Peter Jeng-Jong Lee - Westborough MA, US
John E. O'Gara - Ashland MA, US
John E. O'Gara - Ashland MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
B01D 15/08
US Classification:
2101982, 2105021, 210635, 210656, 502402
Abstract:
Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.
Maldi Sample Plate
US Patent:
2003011, Jun 26, 2003
Filed:
Aug 19, 2002
Appl. No.:
10/223401
Inventors:
Jeff Brown - Cheshire, GB
Dominic Gostick - Cheshire, GB
Edouard Bouvier - Stow MA, US
John Gebler - Hopkinton MA, US
Peter Lee - Westborough MA, US
James Langridge - Cheshire, GB
Emmanuelle Claude - Altrincham, GB
Weibin Chen - Holliston MA, US
Dominic Gostick - Cheshire, GB
Edouard Bouvier - Stow MA, US
John Gebler - Hopkinton MA, US
Peter Lee - Westborough MA, US
James Langridge - Cheshire, GB
Emmanuelle Claude - Altrincham, GB
Weibin Chen - Holliston MA, US
Assignee:
Micromass Limited - Manchester
International Classification:
H01J049/04
US Classification:
250/288000
Abstract:
A MALDI sample plate is disclosed which comprises a metallic substrate having a circular groove or moat . A hydrophobic polytetrafluoroethylene layer is applied to the substrate and a central portion of the substrate is laser etched which roughens the surface of the substrate . A thin polystyrene layer is then applied to the polytetrafluoroethylene layer and the central portion