Inventors:
Sang-Mo Kang - San Francisco CA
Andries Erik Braat - The Hague, NL
Steinunn Baekkeskov - San Francisco CA
Peter G. Stock - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3819
US Classification:
514 2, 530350, 530351, 4353201, 435325, 4353651, 4352523, 43525411, 536 235, 536 231, 424450
Abstract:
This invention generally provides polypeptides comprising a noncleavable form of a Fas ligand and having a capacity to activate a Fas receptor-mediated pathway involved in cell death, pharmaceutical compositions of such polypeptides, nucleic acids encoding such polypeptides, and cell lines capable of expressing these nucleic acids. Also provided are therapeutic and prophylactic methods of using such polypeptides, compositions, and cells lines for treating patients suffering from disorders resulting from dysregulation or inappropriate stimulation of the Fas receptor-mediated pathway.