Inventors:
Peter Canoll - New York NY, US
James Goldman - White Plains NY, US
Marcela Assanah - East Elmhurst NY, US
Sanja Ivkovic - New York NY, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
International Classification:
A61K 35/30, C12N 5/02, C12N 15/87, G01N 33/53, A61P 25/00, A01K 67/027, A61K 31/7088
US Classification:
435464, 435375, 514 44, 424 9321, 800 10, 800 3
Abstract:
The invention is directed to methods for in vivo amplification of neural progenitor cells using the proliferative environment of glial neoplasms in adult brain. The progenitor cells have the capacity to proliferate and differentiate into mature brain cells which can be used for cell replacement therapies. The invention also provides cell replacement therapy methods for treating central nervous system diseases or injuries, including multiple sclerosis, stroke, Alzheimer's disease and Parkinson's disease.