PETER D WRIGHT
Architects in Cambridge, MA
License number
Massachusetts 8016
Issued Date
Sep 20, 1989
Expiration Date
Aug 31, 2017
Type
Architect
Address
Address
Cambridge, MA 02138
Professional information
Synthesis Of Tetracyclines And Intermediates Thereto
US Patent:
2012011, May 10, 2012
Filed:
Apr 30, 2010
Appl. No.:
13/266788
Inventors:
Andrew G. Myers - Boston MA, US
David A. Kummer - La Jolla CA, US
Derun Li - Roselle Park NJ, US
Evan Hecker - Arlington MA, US
Amelie Dion - Cambridge MA, US
Peter M. Wright - Cambridge MA, US
David A. Kummer - La Jolla CA, US
Derun Li - Roselle Park NJ, US
Evan Hecker - Arlington MA, US
Amelie Dion - Cambridge MA, US
Peter M. Wright - Cambridge MA, US
Assignee:
President and Felows of Harvard College - Cambridge MA
International Classification:
A61K 31/65, A61P 31/00, C07D 265/30, C07D 241/04, C07D 261/20, C07C 237/26
US Classification:
514152, 548241, 552205, 544154, 544380, 548528, 546195, 5483351, 546285
Abstract:
Efficient method for preparing the enone intermediate (VII) used in the synthesis of tetracyclines derivatives. In particular, the invention provides a synthesis which allows for substituents at positions 4, 5, 5, and 12of the tetracycline ring system.