Inventors:
Andrew G. Myers - Boston MA, US
David A. Kummer - La Jolla CA, US
Derun Li - Roselle Park NJ, US
Evan Hecker - Arlington MA, US
Amelie Dion - Cambridge MA, US
Peter M. Wright - Cambridge MA, US
Assignee:
President and Felows of Harvard College - Cambridge MA
International Classification:
A61K 31/65, A61P 31/00, C07D 265/30, C07D 241/04, C07D 261/20, C07C 237/26
US Classification:
514152, 548241, 552205, 544154, 544380, 548528, 546195, 5483351, 546285
Abstract:
Efficient method for preparing the enone intermediate (VII) used in the synthesis of tetracyclines derivatives. In particular, the invention provides a synthesis which allows for substituents at positions 4, 5, 5, and 12of the tetracycline ring system.