PETER CHOYKE, M.D.
Radiology in Bethesda, MD

2002013, Sep 26, 2002

Aug 22, 2001

09/934968

Peter Yim - Bethesda MD, US
Peter Choyke - Bethesda MD, US
Mullick Rakesh - Bangalore, IN

G06K009/00

382/131000

An apparatus, article of manufacture, and method for modeling an elongated object located internal to a body (e.g., blood vessels such as the carotid artery or the renal artery). Magnetic resonance data of the area of concern is collected. The magnetic resonance data is analyzed, extracting gradient information. The extracted gradient information may include the gradient of the magnitude gradient. Contemporaneously, a tubular coordinate system is interactively generated as an initial model of the artery. An axis and a reference circumferential direction are defined for the coordinate system with radial lines extending outward from the axis. Intersecting radial lines are merged. All vertices at radial and circumferential positions are initialized with the extracted gradient information. Then, the initialized model is deformed subjecting initialized vertices to image and smoothing forces, thereby completing the surface model of the artery, effectively reconstructing the artery surface. The reconstructed artery surface may be displayed on a display.

8447384, May 21, 2013

Jun 12, 2009

12/993854

Sheng Xu - Rockville MD, US
Jochen Kruecker - Washington DC, US
Guy Shechter - Briarcliff Manor NY, US
Ian Farmer - Capitola CA, US
Peter Lyle Choyke - Bethesda MD, US
Peter Pinto - Bethesda MD, US
Bradford J. Wood - Potomac MD, US

Koninklijke Philips Electronics N.V. - Eindhoven

A61B 5/05

600429, 606130

A method and system for performing biopsies can include an imaging system for obtaining diagnostic images of a target region; a tracking system; a probe having a deployable biopsy needle for performing a biopsy procedure where the tracking system generates tracking information for at least one of the probe and the biopsy needle; an ultrasound imaging system for obtaining ultrasound imaging of the target region; and a computer in communication with the tracking system, the imaging system and the ultrasound imaging system. The computer can register the tracking system with the imaging system. The computer transfers a marking of a biopsy site associated with the biopsy procedure from the ultrasound imaging to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.

5100646, Mar 31, 1992

Jul 25, 1990

7/557038

Peter L. Choyke - Bethesda MD
Joseph A. Frank - Potomac MD
Howard A. Austin - Bethesda MD

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

G01N 3100, G01N 2400, A61K 3128, A61K 3119

424 9

A method of determining the glomerular filtration rate of a subject comprises (1) obtaining a serum sample S. sub. pre and a urine sample U. sub. pre from a subject; (2) administering to the subject an amount of a paramagnetic substance that is filtered by the kidneys and is readily detectable by NMR in serum and urine; (3) allowing for the concentration of the substance to equilibrate between the blood and the extravascular spaces; (4) separating an aliquot of the urine sample v. sub. A and obtaining a serum sample from the subject at the time t. sub. A ; (5) calculating a urine rate (v/a). sub. A from the formula (v/a). sub. A =V. sub. A /a. sub. A ; (6) measuring the magnetic resonance relaxation times of the serum and urine samples, (7) obtaining the concentrations of the paramagnetic substance in the serum samples and the urine samples by comparing their relaxation times to a standard; and (8) calculating GFR from the formula ##EQU1##.

2005017, Aug 4, 2005

Jan 13, 2004

10/756948

Martin Brechbiel - Annandale VA, US
Hisataka Kobayashi - Nishinomiya, JP
Peter Choyke - Bethesda MD, US
John Morris - Rockville MD, US
Thomas Waldmann - Silver Spring MD, US

A61B005/05, A61B005/055

600420000, 424009300

Methods are disclosed for lymphatic system imaging using dendrimer conjugates as contrast agents. The disclosed methods are applicable to the imaging of all lymphatic structures, but in particular embodiments are particularly suited for imaging specific parts of the lymphatic system such as lymph nodes or lymphatic vessels. The methods permit the assessment of abnormal conditions within the lymphatic system, such as lymphoma/lymphoproliferative disease, inflammation, and cancer metastasis. The methods also may be used to identify and locate lymph nodes into which lymph fluid flows from a tumor.

2006020, Sep 14, 2006

Mar 9, 2006

11/371780

Hisataka Kobayashi - Rockville MD, US
Peter Choyke - Bethesda MD, US

A61K 49/10, A61N 5/00, A61K 31/765

424009320, 424078270, 600001000

Methods are disclosed for treating a tumor. A dendrimer conjugate is administered to a subject having a tumor. The dendrimer of the dendrimer conjugate is a generation 5 DAB, generation 2 polylysine, or generation 6-8 PAMAM dendrimer. The dendrimer conjugate comprises an effective amount of an anti-tumor agent. The anti-tumor agent is selectively concentrated in the lymphatic system to treat metastatic disease. In certain examples, the anti-tumor agent is an activatable anti-tumor agent and is activated once the anti-tumor agent is selectively concentrated in the lymphatic system.

2010009, Apr 15, 2010

Mar 17, 2008

12/531841

Ambika Bumb - Greer SC, US
Martin W. Brechbiel - Annandale VA, US
Peter Choyke - Bethesda MD, US
Lars Fugger - Oxfordshire, GB
Peter James Dobson - Oxfordshire, GB

The jUnited States of America as represented by Secretary, Dept. of Health and Human Service - BETHESDA MD
University of Oxford - Oxfordshire

A61K 49/06, A61K 49/18, A61K 49/00

424 129, 424 96, 424 932, 424 94

Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.

8524239, Sep 3, 2013

Jul 11, 2011

13/180111

Hisataka Kobayashi - Laurel MD, US
Peter Choyke - Bethesda MD, US
Makoto Mitsunaga - Rockville MD, US
Marcelino Bernardo - Germantown MD, US

The United States of America as represented by the Secrectary, Department of Health and Human Services - Washington DC

A61K 39/00, A61K 49/00, A61B 5/00

4241781, 424 91, 424 961

The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.