PETER C APRILE
Pharmacy in Elwood, NY
License number
New Jersey 28RI01595200
Issued Date
Jan 8, 1980
Expiration Date
Apr 30, 1995
Category
Pharmacy
Type
Pharmacist
Address
Address
Elwood, NY
Professional information
Cyanocobalamin Low Viscosity Aqueous Formulations For Intranasal Delivery
US Patent:
8003353, Aug 23, 2011
Filed:
Jun 19, 2008
Appl. No.:
12/142240
Inventors:
Steven C. Quay - Edmonds WA, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Assignee:
Par Pharmaceutical, Inc. - Woodcliff Lake NJ
International Classification:
C12P 19/42, A61K 31/70, A01N 43/04, C07H 19/20
US Classification:
435 86, 514 52, 536 264
Abstract:
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1. 1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Cyanocobalamin Low Viscosity Aqueous Formulations For Intranasal Delivery
US Patent:
2012019, Jul 26, 2012
Filed:
Jul 22, 2011
Appl. No.:
13/189061
Inventors:
Steven C. QUAY - Edmonds WA, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Assignee:
PAR PHARMACEUTICALS INC. - Woodcliff Lake NJ
International Classification:
A61K 31/714, A61P 3/02
US Classification:
514 52
Abstract:
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering, intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Cyanocobalamin Low Viscosity Aqueous Formulations For Intranasal Delivery
US Patent:
7229636, Jun 12, 2007
Filed:
Feb 26, 2004
Appl. No.:
10/787385
Inventors:
Steven C. Quay - Edmonds WA, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Assignee:
Nastech Pharmaceutical Company Inc. - Bothell WA
International Classification:
A61F 13/00
US Classification:
424434, 424 173, 514 52, 435 86, 536 264
Abstract:
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1. 1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Cyanocobalamin Low Viscosity Aqueous Formulations For Intranasal Delivery
US Patent:
7404489, Jul 29, 2008
Filed:
Mar 31, 2004
Appl. No.:
10/814399
Inventors:
Steven C. Quay - Edmonds WA, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Assignee:
QOL Medical, LLC - Vero Beach FL
International Classification:
A61F 13/00
US Classification:
206569, 424434, 424 173, 435 86, 536 264
Abstract:
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1. 1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Cyanocobalamin Low Viscosity Aqueous Formulations For Intranasal Delivery
US Patent:
7879349, Feb 1, 2011
Filed:
Mar 27, 2008
Appl. No.:
12/079875
Inventors:
Steven C. Quay - Edmonds WA, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Peter C. Aprile - East Northport NY, US
Zenaida O. Go - Clifton NJ, US
Anthony P. Sileno - Brookhaven Hamlet NY, US
Assignee:
Par Pharmaceutical, Inc. - Woodcliff Lake NJ
International Classification:
A61F 13/00, C07H 23/00, A61K 31/70
US Classification:
424434, 424 773, 514 52, 435 86
Abstract:
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1. 1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.