Inventors:
Maria Virginia Pascual - Dallas TX, US
Jacques F. Banchereau - Dallas TX, US
Damien J. Chaussabel - Richardson TX, US
Ellen Kaizer - Dallas TX, US
Perrin C. White - Dallas TX, US
Assignee:
BAYLOR RESEARCH INSTITUTE - Dallas TX
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
A61K 38/00, A61K 31/70, C12Q 1/68, C12Q 1/02, A61P 3/10, C40B 30/04, G01N 33/53
US Classification:
514 12, 514 44, 435 6, 435 29, 506 9, 435 792, 702 19
Abstract:
The present invention includes composition, methods and systems for detecting, evaluating, diagnosis, tracking and treating Type 1 Diabetes by determining the level of expression of one or more genes listed in Table 1 (e.g., interleukin-1β (IL1B), early growth response gene 3 (EGR3), and prostaglandin-endoperoxide synthase 2 (PTGS2)). The present invention also includes compositions and methods for treating a patient in need thereof with a composition having a therapeutically effective amount of one or more IL-1β antagonists sufficient to spare pancreatic beta cells, including an anti-IL-1β receptor and downstream activators.