MS. PAULINE LEE, L.AC.
Acupuncture at Governor Dr, San Diego, CA

6350593, Feb 26, 2002

Jun 2, 1995

08/459395

Lewis T. Williams - San Francisco CA
Daniel F. Johnson - San Francisco CA
Pauline E Lee - San Diego CA

Regents of the University of California - Alameda CA

C12N 1509

435 694, 435 691, 435325, 4352523, 4352402, 4353201, 536 235, 536 2431, 530350

A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have bee identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electroporated by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors. Methods for evaluating compositions which promoter or inhibit fibroblastic growth factors and compositions which are agonistic or antagonistic to fibroblast growth factor receptors are also provided. Diagnostic and therapeutic uses are described.

6355440, Mar 12, 2002

Jun 2, 1995

08/459082

Lewis T. Williams - San Francisco CA
Daniel F. Johnson - San Francisco CA
Pauline E Lee - San Diego CA

The Regents of the University of California - Alameda CA

G01N 3353

435 71, 435 72, 436501

The present invention relates to receptors for growth factors, specifically to the fibroblast growth factor receptor (FGF-R). More particularly, it provides various purified fibroblast growth factor receptor proteins, nucleic acids encoding the receptor proteins, methods for the production of purified FGF-R proteins, proteins made by these methods, antibodies against these proteins, diagnostic and therapeutic uses of these various reagents, and methods of detecting a fibroblast growth factor in a sample using the disclosed fibroblast growth factor receptors.

5707632, Jan 13, 1998

Jun 2, 1995

8/458938

Lewis T. Williams - San Francisco CA
Daniel E. Johnson - San Francisco CA
Pauline E. Lee - San Diego CA

The Regents of the University of CA - Alameda CA

G01N 3353, C07K 100, C07K 1600, C12P 2108

4241981

A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electrophoresed by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors. Methods for evaluating compositions which promote or inhibit fibroblastic growth factors and compositions which are agonistic or antagonistic to fibroblast growth factor receptors are also provided. Diagnostic and therapeutic uses are described.