PAUL RICHARD SKOLNIK
Medical Practice in Sharon, MA
License number
Pennsylvania MD028281E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Sharon, MA 02067
Pennsylvania
Pennsylvania
Personal information
See more information about PAUL RICHARD SKOLNIK at radaris.comName
Address
Phone
174 Billings St, Sharon, MA 02067
174 Billings St, Sharon, MA 02067
850 Harrison St, Roxbury, MA 02118
Professional information
Cell-Permeable Protein Inhibitors Of Calpain
US Patent:
6867186, Mar 15, 2005
Filed:
Sep 24, 2001
Appl. No.:
09/962967
Inventors:
David A. Potter - Brighton MA, US
Paul Skolnik - Sharon MA, US
Paul Skolnik - Sharon MA, US
Assignee:
New England Medical Center Hospital - Boston MA
International Classification:
A61K038/02, A61K038/55, C07K014/81
US Classification:
514 12, 514 13, 530324, 530325, 530326
Abstract:
Fusion proteins have been discovered that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell. These proteinS can be used to inhibit calpain and may, more specifically, be used to inhibit platelet aggregation or degranulation; to inhibit or reverse erythrocyte sickling; to inhibit a human immunodeficiency virus (HIV); or to inhibit unwanted cellular proliferation or migration.
Cell-Permeable Protein Inhibitors Of Calpain
US Patent:
6294518, Sep 25, 2001
Filed:
Nov 16, 1999
Appl. No.:
9/441416
Inventors:
David A. Potter - Brighton MA
Paul Skolnik - Sharon MA
Paul Skolnik - Sharon MA
Assignee:
New England Medical Center Hospitals, Inc. - Boston MA
International Classification:
A61K 3802, A61K 3855, C07K 1481
US Classification:
514 12
Abstract:
Fusion proteins have been discovered that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell. These proteins can be used to inhibit calpain and, more specifically, to inhibit platelet aggregation or degranulation, to inhibit or reverse erythrocyte sickling, to inhibit a human immunodeficiency virus (HIV), or to inhibit unwanted cellular proliferation or migration.
Cell-Permeable Protein Inhibitors Of Calpain
US Patent:
6015787, Jan 18, 2000
Filed:
Nov 4, 1997
Appl. No.:
8/964302
Inventors:
David A. Potter - Brighton MA
Paul R. Skolnik - Sharon MA
Paul R. Skolnik - Sharon MA
Assignee:
New England Medical Center Hospitals, Inc. - Boston MA
International Classification:
A61K 3802, A61K 3855, C07K 200, C07K 1481
US Classification:
514 12
Abstract:
The invention features fusion proteins that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell, and uses thereof.