PAUL RICHARD ANDERSON
Engineers in Lansdale, PA

5665719, Sep 9, 1997

Jun 6, 1995

8/470693

Mark G. Bock - Hatfield PA
Ben E. Evans - Lansdale PA
Peter D. Williams - Harleysville PA
Roger M. Freidinger - Lansdale PA
Douglas J. Pettibone - Chalfont PA
Doug W. Hobbs - Lansdale PA
Paul S. Anderson - Lansdale PA

Merck & Co., Inc. - Rahway NJ

C07D40102, C07D40302, A61K 3154, A61K 31545

5142278

Compounds of the formula ##STR1## X is --O--, --NH-- and --NR. sup. 8 --; Y is --CH. sub. 2 --, --CHR. sup. 8 -- and --C(R. sup. 8). sub. 2 --; R. sup. 1 is camphor-10-yl, C. sub. 1-5 alkoxyl, styryl, hydroxystyryl, furyl, unsubstituted or substituted thienyl, naphthyl, indolyl, tetrahydronaphthyl, unsubstituted, mono- or di-substituted pyridyl, pyrazinyl, unsubstituted or substituted cyclohexyl where the substituent is R. sup. 4, and unsubstituted or substituted phenyl where the substituents on phenyl are R. sup. 5, R. sup. 6 and R. sup. 7 ; R. sup. 2 is hydrogen, C. sub. 1-5 alkoxy, C. sub. 1-5 alkyl, amino, C. sub. 1-5 alkylcarbonylamino, nitro or halogen; R. sup. 3 is hydrogen, C. sub. 1-5 alkoxycarbonyl, cyano or carbamoyl; R. sup. 4 is one to two of hydrogen, oxo, hydroxy, C. sub.

4064139, Dec 20, 1977

Oct 28, 1976

5/736672

Paul S. Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Gerald S. Ponticello - Lansdale PA

Merck & Co., Inc. - Rahway NJ

C07D48704

2603131

Substituted 9,10-dihydroanthracen-9,10-imines are disclosed to be minor tranquilizers, anticonvulsnts, muscle relaxants, and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.

4414154, Nov 8, 1983

Oct 22, 1981

6/313913

Paul S. Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Ben E. Evans - Lansdale PA
David C. Remy - North Wales PA

Merck & Co. Inc. - Rahway NJ

C07D22508

2602457

Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.

4052508, Oct 4, 1977

Apr 7, 1975

5/564012

Paul S. Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Gerald S. Ponticello - Lansdale PA

Merck & Co., Inc. - Rahway NJ

C07D47108, A61K 31395, C07D48708

424258

Heterocyclic dihydroanthracen imines are disclosed to be useful as minor tranquilizers, anticonvulsants, muscle relaxants and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.

4329465, May 11, 1982

Oct 1, 1979

6/080896

Paul S. Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Ben E. Evans - Lansdale PA
David C. Remy - North Wales PA

Merck & Co., Inc. - Rahway NJ

C07D22118, A61K 3147

546072

Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.

4399141, Aug 16, 1983

Jun 12, 1981

6/272864

Paul Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Ben E. Evans - Lansdale PA

Merck & Co., Inc. - Rahway NJ

A61K 31435, C07D45500

424256

5-Substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anticonvulsants.

4374838, Feb 22, 1983

Oct 22, 1981

6/313900

Paul S. Anderson - Lansdale PA
Marcia E. Christy - Perkasie PA
Ben E. Evans - Lansdale PA
David C. Remy - North Wales PA

Merck & Co., Inc. - Rahway NJ

A61K 31435

424256

Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.

5886046, Mar 23, 1999

Jan 19, 1996

8/588763

Ralph F. Hirschmann - Blue Bell PA
Amos B. Smith - Merion PA
Paul Sprengeler - Philadelphia PA
Wenqing Yao - Lansdowne PA
Paul Anderson - Lansdale PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 31165, C07C23305

514617

This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other medicinally-significant proteins. In particular, the invention relates to dicarbonyl compounds that are capable of acting as enzyme inhibitors, including irreversible inhibitors of HIV-1 protease.

3973017, Aug 3, 1976

Jul 7, 1975

5/593412

Paul S. Anderson - Lansdale PA

Merck & Co., Inc. - Rahway NJ

C07D27916, A61K 3154

424246

Disclosed are 2,3,5,6-tetrahydro-8H-imidazo-[2,1-c][1,4]thiazines, analogues and derivatives thereof which are effective in inhibiting indoleamine-N-methyl transferase and thus useful in the treatment of mental aberrations, such as schizophrenia. Also disclosed are processes for the preparation of such imidazothiazines; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.

4252810, Feb 24, 1981

Nov 15, 1978

5/960811

Paul S. Anderson - Lansdale PA
Ben E. Evans - Lansdale PA

Merck & Co., Inc. - Rahway NJ

A61K 3138, A61K 3144, C07D49512

424256

9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.