DR. PAUL R. BRAKEMAN, M.D.
Medical Practice at Parnassus Ave, San Francisco, CA

6780600, Aug 24, 2004

Jul 20, 2001

09/910706

Paul F. Worley - Baltimore MD
Paul R. Brakeman - San Francisco CA

The Johns Hopkins University School of Medicine - Baltimore MD

G01N 3353

435 71, 435 75, 435 78, 435 79, 435 791, 435 792, 435 793, 435 794, 435 795

Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

7399830, Jul 15, 2008

Jun 10, 2004

10/866256

Paul F. Worley - Baltimore MD, US
Paul R. Brakeman - San Francisco CA, US

Johns Hopkins University - Baltimore MD

C07K 14/435

530350

Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

6294355, Sep 25, 2001

Mar 13, 1998

9/042428

Paul F. Worley - Baltimore MD
Paul R. Brakeman - San Francisco CA

The Johns Hopkins University School of Medicine - Baltimore MD

C12N 1512

435 691

Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.