Inventors:
H. Fred Clark - Philadelphia PA
Paul Offit - Philadelphia PA
Stanley A. Plotkin - Paris, FR
Assignee:
The Wistar Institute of Anatomy & Biology - Philadelphia PA
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
A61K 3912, A61K 39295, C12N 700, C12Q 170
Abstract:
The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v. p. 7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v. p. 4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.