Inventors:
Paul E. Monahan - Chapel Hill NC, US
Richard Jude Samulski - Chapel Hill NC, US
Joseph E. Rabinowitz - Carrboro NC, US
Assignee:
University of North Carolina - Chapel Hill - Chapel Hill NC
International Classification:
A61K 48/00, A61K 39/23
Abstract:
The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i. e. , sutures, surgically implantable materials, grafts, and the like).