PAUL MISCHEL, MD
Medical Practice in Los Angeles, CA

2009016, Jun 25, 2009

Sep 30, 2005

11/576444

Harley I. Kornblum - Los Angeles CA, US
Daniel H. Geschwind - Santa Monica CA, US
Ichiro Nakano - Los Angeles CA, US
Joseph D. Dougherty - New York NY, US
Jorge Lazareff - Los Angeles CA, US
Paul S. Mischel - Los Angeles CA, US
Michael D. Masterman Smith - Playa Del Rey CA, US
Jing Huan - Los Angeles CA, US
Houman D. Hemmati - Baltimore MD, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

A61K 31/70, A61K 31/7088, A61K 38/02, A61K 38/16, A61K 31/20, C40B 40/08, G01N 33/53, A61P 35/00

514 12, 514 44, 514 2, 514 23, 514558, 506 17, 435 721

In one aspect, the invention provides composition and methods for the diagnosis, prognosis and treatment of tumors and cancers, e.g., brain cancers. In one aspect, the invention provides compositions and methods for inhibiting the growth, proliferation, differentiation and/or survival of a neural stem cell or a cancer cell, or progenitor stem cell thereof. In one aspect, the invention provides compositions and methods for identifying the genetic profile of a brain cancer cell or a self-renewing neural cancer stem cell. In one aspect, the invention provides methods employing these profiles to identify compounds that inhibit tumor growth.

2010029, Nov 18, 2010

Feb 2, 2009

12/863526

Kenichiro Kamei - Los Angeles CA, US
Jing Sun - Los Angeles CA, US
Paul S. Mischel - Los Angeles CA, US
Michael D. Masterman-Smith - Playa Del Rey CA, US
David A. Nathanson - Playa Del Rey CA, US
Tiffany Huang - Los Angeles CA, US
Michael Van Dam - Glendale CA, US
Christian Behrenbruch - Los Angeles CA, US
Shawn M. Sarkaria - Los Angeles CA, US

The Regents of the University of California - Oakland CA

C12Q 1/68, C12M 1/34, G01N 33/50

435 6, 4352887, 435 721

A microfluidic system has a pipette system comprising a plurality of pipettes, a microfluidic chip arranged proximate the pipette system, an imaging optical detection system arranged proximate the microfluidic chip, and an image processing system in communication with the imaging optical detection system. The microfluidic chip has a plurality of cell culture chambers defined by a body of the microfluidic chip, each cell culture chamber being in fluid connection with an input channel and an output channel defined by the microfluidic chip. The pipette system is constructed and arranged to at least one of inject fluid through the plurality of pipettes into the plurality of input channels or extract fluid through the plurality of pipettes from the plurality of output channels while the microfluidic system is in operation.

2011004, Feb 24, 2011

Apr 21, 2006

11/918916

Paul S. Mischel - Los Angeles CA, US
Ingo K. Mellinghoff - Los Angeles CA, US
Yinglin Wang - Los Angeles CA, US
Timothy F. Cloughesy - Encino CA, US
Charles L. Sawyers - Los Angeles CA, US

C12Q 1/68, G01N 33/574, C12Q 1/42

435 6, 435 723, 435 21

The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregulated in pathologies such as cancer and to reagents and kits adapted for performing such methods.

2004010, Jun 3, 2004

Nov 5, 2003

10/701490

Paul Mischel - Los Angeles CA, US
Charles Sawyers - Los Angeles CA, US
Bradley Smith - Marblehead MA, US
Katherine Crosby - Middleton MA, US

The Regents of the University of California

C12Q001/68, G01N033/574

435/006000, 435/007230

The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregulated in pathologies such as cancer and to reagents and kits adapted for performing such methods.