PAUL J LYNCH
Marriage and Family Therapists in Arlington, MA
License number
Massachusetts 953
Issued Date
Sep 21, 1993
Expiration Date
Dec 31, 2009
Type
Marriage and Family Therapist
Address
Address
Arlington, MA 02476
Professional information
High Purity Lipopeptides, Lipopeptide Micelles And Processes For Preparing Same
US Patent:
6696412, Feb 24, 2004
Filed:
Nov 28, 2000
Appl. No.:
09/735191
Inventors:
Thomas J. Kelleher - Weston MA
Joseph P. DeCourcey - Charlestown MA
Paul Lynch - Arlington MA
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
Joseph P. DeCourcey - Charlestown MA
Paul Lynch - Arlington MA
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
Assignee:
Cubist Pharmaceuticals, Inc. - Lexington MA
International Classification:
C07K 750
US Classification:
514 9, 514 11, 514 2, 514 14, 530317, 530322, 530344, 435886
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
High Purity Lipopeptides
US Patent:
8604164, Dec 10, 2013
Filed:
Feb 16, 2012
Appl. No.:
13/398219
Inventors:
Thomas J. Kelleher - Thousand Oaks CA, US
Joseph P. DeCourcey - Boston MA, US
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
Joseph P. DeCourcey - Boston MA, US
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
Assignee:
Cubist Pharmaceuticals, Inc. - Lexington MA
International Classification:
C07K 7/00, C07K 7/50
US Classification:
530317, 530327, 530344, 514 211, 514 215
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
High Purity Lipopeptides
US Patent:
8129342, Mar 6, 2012
Filed:
Sep 22, 2010
Appl. No.:
12/888233
Inventors:
Thomas J. Kelleher - Thousand Oaks CA, US
Joseph P. DeCourcey - Boston MA, US
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
Joseph P. DeCourcey - Boston MA, US
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
Assignee:
Cubist Pharmaceuticals, Inc. - Lexington MA
International Classification:
C07K 7/50, C07K 7/00
US Classification:
514 9, 514 11, 514 2, 514 14, 530317, 530322, 530344, 435886
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
High Purity Lipopeptides
US Patent:
8058238, Nov 15, 2011
Filed:
Apr 24, 2007
Appl. No.:
11/739180
Inventors:
Thomas Kelleher - Weston MA, US
Joseph P. DeCourcey - Charlestown MA, US
Paul Lynch - Arlington MA, US
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
Joseph P. DeCourcey - Charlestown MA, US
Paul Lynch - Arlington MA, US
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
Assignee:
Cubist Pharmaceuticals, Inc. - Lexington MA
International Classification:
C07K 7/50, C07K 7/00
US Classification:
514 9, 514 11, 514 2, 514 14, 530317, 530322, 530344, 435886
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
High Purity Lipopetides
US Patent:
2013028, Oct 24, 2013
Filed:
Jun 14, 2013
Appl. No.:
13/918083
Inventors:
Joseph P. DeCourcey - Boston MA, US
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
Paul D. Lynch - Arlington MA, US
Maurizio Zenoni - Ferentino Frosinone, IT
Auro R. Tagliani - Pavia, IT
International Classification:
C07K 1/14
US Classification:
435 701
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of . The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
High Purity Lipopeptides
US Patent:
2005000, Jan 13, 2005
Filed:
Dec 29, 2003
Appl. No.:
10/747485
Inventors:
Thomas Kelleher - Weston MA, US
Joseph DeCourcey - Charlestown MA, US
Paul Lynch - Arlington MA, US
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
Joseph DeCourcey - Charlestown MA, US
Paul Lynch - Arlington MA, US
Maurizio Zenoni - Milan, IT
Auro Tagliani - Pavia, IT
International Classification:
A61K038/16, A61K038/17
US Classification:
514012000
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.