Inventors:
Paul G. Yock - Stanford CA
Ali H. Hassan - Stanford CA
Alan Ching Yeun Yeung - Stanford CA
Andrew Carter - Stanford CA
Mehrdad Rezaee - Stanford CA
Niall Herity - Stanford CA
Sidney Lo - Stanford CA
Peter J. Fitzgerald - Stanford CA
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61M 2500
US Classification:
604508, 604507, 514 2, 514 44, 514 54
Abstract:
Methods are provided for locally administering an agent to a host. Specifically, the subject methods provide for the local administration of an agent to an interstitial space of a host. In the subject methods, an agent is retroinfused into a vessel of a host, typically a vein, under conditions sufficient for the agent to enter an interstitial space of the host proximal to the vessel location into which the agent is retroinfused. In practicing the subject methods, the agent is administered to the host in combination with the production of vascular stress at the site of administration, where the vascular tissue stress is sufficient to provide for transport of the agent from the vascular site of deposition into the target interstitial space. In a preferred embodiment, the agent is retroinfused at a pressure sufficient to provide for mechanical stress on the vessel proximal to the target interstitial space. Also provided are kits for use in practicing the subject methods.