Inventors:
Urszula Slomczynska - Ballwin MO, US
Paul Olivo - Clayton MO, US
Jodi Beattie - Wentzville MO, US
Gale Starkey - St.Llouis MO, US
Amine Noueiry - St. Louis MO, US
Robert Roth - St. Louis MO, US
International Classification:
A61K 38/21, A61K 31/519, A61K 31/7056, A61P 31/14, A61K 31/7088, A61K 39/395, C07H 21/00, C12Q 1/70, C07D 487/04, A61K 31/713
US Classification:
424 854, 544281, 5142593, 514 43, 514 44 A, 4241301, 536 2372, 435 5
Abstract:
Various tetrahydropyrazolo[1,5-a]pyrimidine compounds, compositions, methods of making, and methods for the prevention and treatment of HCV infections and associated diseases are disclosed. The invention further relates to biomarkers for identification of HCV strains which are resistant to the tetrahydropyrazolo[1,5-a]pyrimidine compounds.