PAUL ANTHONY SPENCE, M.D.
Radiology at Orion Rd, Louisville, KY

6488692, Dec 3, 2002

Mar 7, 2000

09/520468

Paul A. Spence - Louisville KY
George Christakis - Toronto, CA

Origin Medsystems, Inc. - Menlo Park CA

A61B 1704

606153, 606139

An access and cannulation device includes a mounting element such as the anastomosis mounting element disclosed in U. S. application Ser. No. 08/714,615 (now U. S. Pat. No. 5,868,763) and U. S. application Ser. No. 09/200,796. The device is used to provide access therethrough and via an incision to the interior of a hollow anatomical structure such as a vessel, an organ or the like during surgery, especially minimally invasive surgery. It includes a flexible sleeve with a suture therein for closing the sleeve and locating edges of the structure adjacent to the incision in position for proper healing after completion of a surgical procedure. A tool is also disclosed for manipulating the device to configure it for the surgery and to close it after completion of the surgery whereby the edges of the wall of the structure adjacent to an incision are approximated to promote proper healing.

6705988, Mar 16, 2004

Dec 28, 2001

10/029792

Paul A. Spence - Louisville KY
Warren Williamson, IV - Loveland OH

Origin Medsystems, Inc. - Santa Clara CA

A61B 132

600201, 600 37

A system for manipulating and supporting a beating heart during cardiac surgery, including a gross support element for engaging and supporting the heart (the gross support element preferably including a head which is sized and shaped to cradle the myocardium of the left ventricle”), a suspension head configured to exert lifting force on the heart when positioned near the apical region of the heart at a position at least partially overlying the right ventricle, and a releasable attachment element for releasably attaching at least one of the gross support element and the suspension head to the heart. The releasable attachment element can be a mechanical element (such as one or more staples or sutures) or an adhesive such as glue. Alternatively, the system includes a suspension head and a releasable attachment element for releasably attaching it to the heart, but does not include a gross support element.

2002016, Oct 31, 2002

Mar 27, 2002

10/113731

Paul Spence - Louisville KY, US
Warren Williamson - Loveland OH, US

A61B001/32

600/210000

Mechanical elements and/or adhesive is used in conjunction with or in place of suction to releasably attach elements of a system for manipulating a heart during cardiac surgery to the heart. The elements of the heart manipulation system are disclosed in the application Ser. No. 09/087,511 filed on May and in the patent application Ser. No. 08/936,184 filed on Sept. 17, 1997. One form of the system can be used in minimally invasive surgery.

6718985, Apr 13, 2004

May 25, 2001

09/866550

Edwin J. Hlavka - Palo Alto CA 94301
Jonathan L. Podmore - San Francisco CA 94118-2842
Paul A. Spence - Louisville KY 40222

A61B 1900

128898, 623904, 623 236

The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing annuloplasty includes accessing a left ventricle of a heart to provide a discrete plication element to the left ventricle, and engaging the plication element to tissue near a mitral valve of the heart. Engaging the plication element includes causing the plication element to gather a portion of the tissue to create a plication. In one embodiment, accessing the left ventricle of the heart to provide the plication element includes accessing the left ventricle of the heart using a catheter arrangement.

2008014, Jun 12, 2008

Dec 12, 2007

11/954438

Paul A. Spence - Louisville KY, US

A61M 29/00, A61F 2/06

606200, 623 11

A device for preventing stroke due to embolic material in the bloodstream of a patient, the patient having an aorta with an ascending portion and a descending portion, and one or more arch vessels communicating with the aorta for directing blood flow to the brain of the patient. The device includes a physical deflector element configured for at least partial placement in the aorta of the patient and a mounting structure coupled to the physical deflector element. The mounting structure is configured to engage at least one of the aorta or an arch vessel communicating with the aorta. The physical deflector element is constructed and arranged to direct blood flow in the aorta in a manner that directs embolic material in the blood flow past the one or more arch vessels and into the descending portion of the aorta.

2005012, Jun 9, 2005

Jan 31, 2005

10/949133

Paul Spence - Louisville KY, US
Mark Maguire - San Mateo CA, US
Walter Bruszewski - San Francisco CA, US
Michael Sansoucy - Plainville MA, US
Ed McNamara - Chelmsford MA, US

A61B019/00, A61F002/24

606144000, 227175100, 606151000, 623002360

Catheter based systems and methods for securing tissue including the annulus of a mitral valve. The systems and methods employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

6309417, Oct 30, 2001

May 12, 1999

9/310891

Paul A. Spence - Louisville KY
Mark Ortiz - Milford OH

A61F 200

623 211

Apparatus and methods for replacing a heart valve within a vessel. The apparatus includes a replacement heart valve and a plurality of commisure stabilizers connected to the commisures of the heart valve in a removable manner. The commisure stabilizers position and stabilize the commisures in the proper positions as the replacement heart valve is secured within the vessel. The commisure stabilizers may be removed following securement of the replacement heart valve within the vessel. An expansion or retraction device of the invention assists in properly positioning the valve within the vessel.

6254617, Jul 3, 2001

Nov 27, 1998

9/200796

Paul A. Spence - Louisville KY
Warren P. Williamson - Loveland OH
George Christakis - Toronto, CA

Origin Medsystems, Inc. - Menlo Park CA

A61B 1704

606153

An anastomosis is performed using a mounting structure mounted on the outside of at least one vessel. The mounting structure includes a flexible mounting structure that is attached to the vessel by a special instrument. A graft vessel is attached to the mounting structure either directly or by means of another mounting structure attached to the graft vessel. Tools for attaching a mounting structure to a vessel are disclosed, and a tool for attaching two mounting structures together is also disclosed. Methods for carrying out the anastomosis according to the invention are also disclosed.

6883522, Apr 26, 2005

Nov 19, 2003

10/716844

Paul A. Spence - Louisville KY, US
Mark Ortiz - Milford OH, US

A61B019/00, A61F002/24

128898, 623 211

Apparatus and methods for replacing a heart valve within a vessel. The apparatus includes a replacement heart valve and a plurality of commisure stabilizers connected to the commisures of the heart valve in a removable manner. The commisure stabilizers position and stabilize the commisures in the proper positions as the replacement heart valve is secured within the vessel. The commisure stabilizers may be removed following securement of the replacement heart valve within the vessel. An expansion or retraction device of the invention assists in properly positioning the valve within the vessel.

8142493, Mar 27, 2012

Jul 22, 2008

12/177554

Paul A. Spence - Louisville KY, US
Walter Bruszewski - San Francisco CA, US
Ed McNamara - Chelmsford MA, US
Mark Maguire - San Mateo CA, US

Mitralign, Inc. - Tewksbury MA

A61F 2/24

623 236, 623904

Catheter based systems and methods for securing tissue including the annulus of a mitral valve. The systems and methods employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.