Inventors:
Elizabeth Brooke Hutchinson - Middleton WI, US
Mary Elizabeth Meyerand - Cross Plains WI, US
Paul Anthony Rutecki - Madison WI, US
Thomas Peter Sutula - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 31/7004
Abstract:
This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs thereof. The invention also provides pharmaceutical compositions of 2-DG or glycolysis-inhibiting analogs thereof for use in the methods of the invention.