Inventors:
Robyn Gail Karlstadt Meyeroff - Cherry Hill NJ, US
Ronald joseph Diebold - Chalfont PA, US
David Montague Pierce - Bedfordshire, GB
Patrick T. Martin - Gwynedd Valley PA, US
Assignee:
Shire Development Inc. - Wayne PA
International Classification:
A61K 31/606, A61P 1/04, A61P 1/06
Abstract:
The present invention provides methods of treating inflammatory bowel disease comprising administering to a subject in which remission has not been achieved after a first treatment of about 4-8 weeks of 5-ASA (mesalamine or 5-ASA), a further daily dose greater than about 4 g of 5-ASA in controlled release form to achieve a favorable response to treatment.