MR. PATRICK MILLER, LMT
Massage Therapy at Cohn St, New Orleans, LA

8304521, Nov 6, 2012

Jun 3, 2009

12/477541

Andrew D. Hollenbach - New Orleans LA, US
Patrick J. Miller - New Orleans LA, US
Kevin N. Dietz - New Orleans LA, US

Board of Supervisors of Louisiana State University And Agricultural and Mechanical College - Baton Rouge LA

C07K 5/00, G01N 33/53

530352, 436517, 436547, 436 35, 435 71, 530324

Pax3, a member of the paired class homeodomain family of transcription factors and an essential protein for early skeletal muscle development, was shown to be phosphorylated in proliferating mouse primary myoblasts. Furthermore, Ser205, Ser201 and Ser209 were identified as the only sites of phosphorylation on Pax3 in proliferating mouse primary myoblasts. Phosphorylation of Ser205 was shown to be required for the efficient phosphorylation of Ser201 and/or Ser209. Site-specific antibodies were made to each of these three sites when phosphorylated. These three sites are also present and phosphorylated in the Pax3-FOXO1 fusion protein, and phosphorylation of these sites may play a role in ARMS. Thus, these new antibodies may be used in studying the regulation of nerve and muscle development and differentiation and in finding therapeutic solutions for certain disorders, including Waardenburg syndrome and childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS).

5678826, Oct 21, 1997

Dec 4, 1995

8/566481

Patrick Lee Miller - Kansas City MO

Orbseal, Inc. - Excelsior Springs MO

F16J 900, B29B 1300

277 1

A vehicle body pillar has a cavity therein through which air flow creates undesirable noise and in which moisture and fluids such as water are not to be collected. An expandable sealant plug is inserted therein and retained in place by one or more extractable retainers. The sealant material forming the plug is later expanded and cured under controlled conditions, sealing the cavity so as to prevent the flow of air through it. The expanded sealant also effectively blocks the intrusion of fluids such as water, minimizing corrosion within the pillar. The extractable retainers are then removed and permanent retainers used to hold moldings or the like in place. The sealant also seals the permanent retainers. In other instances, the same type of extractable retainers used with the expandable sealant may be used with a hot melt sealant which, when melted, provides sealing for the later-installed permanent fasteners and the apertures through which they extend.