Inventors:
Shaoling Huang - Sugar Land TX, US
Robert C. MacDonald - El Cerrito CA, US
Patrick Kee - Houston TX, US
David McPherson - Houston TX, US
Assignee:
NORTHWESTERN UNIVERSITY - Evanston IL
International Classification:
A61K 9/127, A61P 9/10
Abstract:
The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).