Inventors:
Francisco Villarreal - Chula Vista CA, US
Katrina Go Yamazaki - La Jolla CA, US
Pam Rajendran Taub - San Diego CA, US
Alan Maisel - Solana Beach CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 31/65, A61K 31/353, C07C 237/26, C12N 5/071, C12Q 1/68, G01N 33/53, C40B 30/00, A61P 9/10, A61P 9/12, A61P 9/00, A61P 25/00
US Classification:
514154, 514456, 552203, 435375, 435 6, 436501, 506 7
Abstract:
The disclosure provides a method of reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof, wherein the subject is a human or a veterinary animal. Additionally the disclosure provides a method of treating subarachnoid hemorrhage or atrial fibrillation or of enhancing or preserving migration, seeding, proliferation, differentiation and/or survival of stem cells in injured heart tissue comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof. The effects of epicatechin administration are sustained over time.