PABLO LEON
Medical Practice in Philadelphia, PA
License number
Pennsylvania MD044861E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Philadelphia, PA 19130
Personal information
See more information about PABLO LEON at radaris.comName
Address
Phone
522 Cornwall St, Philadelphia, PA 19140
Professional information
See more information about PABLO LEON at trustoria.com
Quinolinone Pde2 Inhibitors
Quinolinone Pde2 Inhibitors
US Patent:
2012011, May 10, 2012
Filed:
Jul 19, 2010
Appl. No.:
13/384946
Inventors:
Pablo De Leon - Philadelphia PA, US
Melissa Egbertson - Ambler PA, US
Ivory D. Hills - Harleysville PA, US
Adam Wayne Johnson - North Wales PA, US
Michelle Machacek - Brookline MA, US
Melissa Egbertson - Ambler PA, US
Ivory D. Hills - Harleysville PA, US
Adam Wayne Johnson - North Wales PA, US
Michelle Machacek - Brookline MA, US
International Classification:
A61K 31/4709, C07D 409/04, C07D 215/22, A61K 31/4704, A61P 25/18, C07D 401/12, A61P 25/22, A61P 25/00, A61P 25/16, C07D 409/14, A61K 31/506
US Classification:
514256, 546157, 514312, 544333
Abstract:
The present invention is directed to quinolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
2-[1-Phenyl-5-Hydroxy-4A-Substituted-Hexahydrocyclopenta[F]Indazol-5-Yl]Ethyl Phenyl Derivatives As Glucocorticoid Receptor Ligands
2-[1-Phenyl-5-Hydroxy-4A-Substituted-Hexahydrocyclopenta[F]Indazol-5-Yl]Ethyl Phenyl Derivatives As Glucocorticoid Receptor Ligands
US Patent:
2012021, Aug 23, 2012
Filed:
Oct 26, 2010
Appl. No.:
13/504260
Inventors:
Christopher James Bungard - Lansdale PA, US
James J. Perkins - Churchville PA, US
Jesse J. Manikowski - Norristown PA, US
Pablo de Leon - Philadelphia PA, US
Robert S. Meissner - Schwenksville PA, US
James J. Perkins - Churchville PA, US
Jesse J. Manikowski - Norristown PA, US
Pablo de Leon - Philadelphia PA, US
Robert S. Meissner - Schwenksville PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/4439, C07D 401/10, C07D 231/54, A61P 41/00, A61P 35/02, A61P 37/00, A61P 3/10, A61P 3/04, A61P 3/00, A61P 1/00, A61P 19/02, A61P 37/08, A61P 11/00, A61P 11/06, A61P 21/00, A61P 31/14, A61P 29/00, A61P 17/06, A61P 17/00, A61P 17/10, A61P 31/18, A61P 35/00, A61P 25/00, A61P 25/24, A61P 25/18, A61P 25/20, A61P 25/22, C07D 401/04, A61K 31/416
US Classification:
514338, 514406, 5462757, 5483565
Abstract:
The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.