Inventors:
Olufunmilayo I. Olopade - Chicago IL, US
Assignee:
Arch Development Corporation - Chicago IL
International Classification:
C12Q 1/68, G01N 33/53, A61K 38/00, C07K 16/00, C07H 21/04
US Classification:
435 6, 435 71, 530324, 5303879, 536 235, 536 2431
Abstract:
Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.