OLGA BAJENOVA
Broker in Somerville, MA
License number
Massachusetts 9512194
Issued Date
Jun 19, 2009
Expiration Date
Sep 15, 2017
Type
Salesperson
Address
Address
Somerville, MA 02143
Professional information
Compositions And Methods To Prevent Metastasis From Primary Malignancies
US Patent:
2005005, Mar 17, 2005
Filed:
Mar 21, 2002
Appl. No.:
10/468388
Inventors:
Peter Thomas - Pembroke, MA, US
Olga Bajenova - Somerville MA, US
Olga Bajenova - Somerville MA, US
International Classification:
C12Q001/68, G01N033/574, C07H021/04, A61K039/395, C12N009/64
US Classification:
424155100, 514044000, 435006000, 435007230, 435069100, 435226000, 435320100, 435325000, 530388260, 536023200
Abstract:
We have now discovered a new method for treating carcinoembriyonic antigen (CEA) associated cancers. This involves blocking a protein expressed by the hnRNP M4 gene (preferably the human hnRNP M4 gene). We identified and isolated a liver-derived recombinant cDNA clone, termed heterogeneous nuclear RNA binding protein M4 (hnRNP M4) SEQ ID NO: 1, from rat macrophages Kupffer cells (KC) that encodes a novel protein interacting with CEA molecules and is 91% homologous with the deletion mutant of the human hnRNP M4 gene (# U32577). The novel protein is, hereinafter, considered as one protein population with the human homologue and referred to herein as hnRNP M4 CEA receptor, or hnRNP M4.