OHENEBA BOACHIE-ADJEI, MD
Medical Practice at 72 St, New York, NY

6939540, Sep 6, 2005

Jul 31, 2000

09/629074

Ronald G. Crystal - Potomac MD, US
Chisa Hidaka - New York NY, US
Oheneba Boachie-Adjei - New York NY, US
Bernard A. Rawlins - Englewood NJ, US
Imre Kovesdi - Rockville MD, US

Cornell Research Foundation, Inc. - Ithaca NY
The Hospital for Special Surgery - New York NY
GenVec, Inc. - Gaithersburg MD

A01N063/00, A01N043/04, A61K048/00, C12N005/00, C12N015/00

424 932, 424 931, 424 9321, 4353201, 435325, 435455, 514 44

The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding an osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.

2010008, Apr 1, 2010

Mar 27, 2009

12/413013

Daryl R. Sybert - New Albany OH, US
Sigurd Berven - SanFrancisco CA, US
Randal R. Betz - Ocean City NJ, US
Oheneba Boachie-Adjei - New York NY, US
Scott Boden - Atlanta GA, US
Michael F. O'Brien - Coral Gables FL, US
Alexis P. Shelokov - Plano TX, US
John M. Winterbottom - Howell NJ, US

A61B 17/84, A61B 17/56

606326, 606 86 R

Bone anchors and related methods for their use are described. The inventive anchor is suitable for placement in bone and for use in orthopedic surgery and dentistry. The bone anchor can be made from a bone/polymer or bone substitute/polymer composite, and can provide a firm and secure base for attaching a fastening device. The bone anchor can be used in various orthopedic and dental procedures including spinal surgery, where normal, cancellous, cortical, diseased or osteoporotic bone is present. The bone anchor can be resorbed and/or replaced with native bone tissue over a period of time. In certain embodiments, the bone anchor is made malleable or flowable and formed in situ or in vivo.