NORMAN WOLMARK, MD
Radiology at Ave, Pittsburgh, PA

6786902, Sep 7, 2004

Mar 16, 2000

09/527491

Yoed Rabin - Pittsburgh PA
Thomas Benjamin Julian - Pittsburgh PA
Norman Wolmark - Pittsburgh PA

Allegheny-Singer Research Institute - Pittsburgh PA

A61B 1736

606 23, 606 21, 606 22, 128898

The present invention pertains to an apparatus for cryosurgery. The apparatus comprises a cryoneedle having a diameter less than 3. 2 mm. The apparatus is also comprised of a thermal insulation shell disposed about a portion of the cryoneedle for reduction of heat transfer from surrounding tissues or freezing prevention of surrounding tissues during application of the cryoneedle with the shell. The cryoneedle and shell are configured for insertion into a body of a patient. The present invention pertains to a method for freezing tissues. The method comprises the steps of bringing into contact a cryoneedle having a diameter of less than 3. 2 mm with a patients body. Next, there is the step of flowing the cryofluid through the cryoneedle.

5899897, May 4, 1999

Sep 25, 1997

8/936958

Yoed Rabin - Pittsburgh PA
Thomas Benjamin Julian - Pittsburgh PA
Norman Wolmark - Pittsburgh PA

Allegheny-Singer Research Institute - Pittsburgh PA

A61B 1736

606 21

The system includes a mechanism for freezing tissue in a patient. Additionally, the system includes a mechanism for heating other tissue near the tissue being frozen by the freezing mechanism such that essentially only desired region is frozen by the freezing mechanism and heat from the heating mechanism prevents the other tissue from being frozen. The heating mechanism is disposed adjacent to but separate and apart from the freezing mechanism. Alternatively, the mechanism for heating can be used with tissue already frozen by the freezing mechanism. A method for performing cryosurgery on a patient. The method includes the steps of inserting a cryoprobe into a patient. Next, there is the step of placing a cryoheater in contact with the patient adjacent the cryoprobe. Then, there is the step of activating the cryoprobe and the cryoheater so the cryoprobe freezes desired tissue in the patient and the cryoheater heats other tissue around the desired tissue so the other tissue is not frozen by the cryoprobe. Alternatively, there can be the step of activating the cryoheater after the cryoprobe has frozen the desired tissue to thaw the frozen tissue.

6039730, Mar 21, 2000

Jun 24, 1996

8/668692

Yoed Rabin - Pittsburgh PA
Thomas Benjamin Julian - Pittsburgh PA
Norman Wolmark - Pittsburgh PA

Allegheny-Singer Research Institute - Pittsburgh PA

A61B 1736

606 23

The present invention pertains to an apparatus for cryosurgery. The apparatus comprises a cryoneedle having a diameter less than 3. 2 mm. The apparatus is also comprised of a thermal insulation shell disposed about a portion of the cryoneedle for reduction of heat transfer from surrounding tissues or freezing prevention of surrounding tissues during application of the cryoneedle with the shell. The cryoneedle and shell are configured for insertion into a body of a patient. The present invention pertains to a method for freezing tissues. The method comprises the steps of bringing into contact a cryoneedle having a diameter of less than 3. 2 mm with a patient's body. Next, there is the step of flowing the cryofluid through the cryoneedle.

2010026, Oct 21, 2010

Apr 20, 2010

12/763704

Eric Hedrick - Summit NJ, US
Robert D. Mass - Mill Valley CA, US
Gwendolyn Fyfe - San Francisco CA, US
Norman Wolmark - Pittsburgh PA, US

A61K 39/395, A61P 35/00

4241331, 4241581

Disclosed herein are methods and compostions comprising anti-VEGF antibodies for use in adjuvant cancer therapy.