Inventors:
Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL
International Classification:
A01N 3718
Abstract:
The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.