Inventors:
Victor M. UGAZ - College Station TX, US
Nitin AGRAWAL - Charlestown MA, US
Assignee:
TEXAS A&M UNIVERSITY SYSTEM - College Station TX
International Classification:
C12P 19/34, C12M 1/00
Abstract:
A closed loop convective flow thermocycler for amplifying DNA sequences via polymerase chain reaction establishes buoyancy driven flow in response to an applied temperature gradient, so that PCR reagents are continuously cycled among temperature zones corresponding to denaturing, annealing and extension temperatures.