Inventors:
Nikolaus S. Trede - Salt Lake City UT, US
International Classification:
A61K 31/4402, A61K 31/4439, A61K 31/495, A61K 31/421, A61K 31/52, A61K 31/341, A61K 31/415, A61K 31/4184, A61P 19/02, A61P 25/00
US Classification:
51425503, 514353, 514339, 514338, 514374, 51426333, 514461, 514403, 514395
Abstract:
Disclosed are compounds and compositions that modulate T-cells. Such compounds can be used to treat T-cell mediated disease like T-ALL, rheumatoid arthritis, multiple sclerosis, and graft-vs-host disease (GvHD), to name but a few. The compounds have a general structure as shown in Formula I.wherein Arand Ar, are independent of one another, a substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl; and L is a bond or a linker spanning two, three, four, or five atoms.