Inventors:
Chen Chen - San Diego CA, US
Fabio Tucci - San Diego CA, US
Joe Tran - San Marcos CA, US
Caroline Chen - San Diego CA, US
Nicole White - San Diego CA, US
Assignee:
Neurocrine Biosciences, Inc. - San Diego CA
International Classification:
A61K031/55, A61K031/496, A61K031/495, C 07D 4 9/02, C 07D 4 5/02
US Classification:
514/218000, 514/252130, 514/254100, 514/255010, 540/575000, 544/374000, 544/386000
Abstract:
Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I):
including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, B, m, n,p, q, r, s, t, R, R, R, R, R, R, R, X, Y, Y, and Yare as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.