DR. NICOLE GABRIELE COUFAL, M.D.
Medical Practice at Childrens Way, San Diego, CA
License number
California A124395
Category
Medical Practice
Type
Pediatrics
Address
Address
3020 Childrens Way, San Diego, CA 92123
Phone
(858) 576-1700
Personal information
See more information about NICOLE GABRIELE COUFAL at radaris.comName
Address
Phone
4845 50Th St, San Diego, CA 92115
360 Winamar Ave, La Jolla, CA 92037
Professional information
See more information about NICOLE GABRIELE COUFAL at trustoria.com
Dr. Nicole G Coufal, San Diego CA - MD (Doctor of Medicine)
Dr. Nicole G Coufal, San Diego CA - MD (Doctor of Medicine)
Specialties:
Pediatrics
Address:
3020 Childrens Way, San Diego 92123
Languages:
English
Education:
Medical School
University of California At San Diego
Graduated: 2006
University of California At San Diego
Graduated: 2006
Retroelements And Mental Disorders And Methods Of Measuring L1 Retrotransposition
Retroelements And Mental Disorders And Methods Of Measuring L1 Retrotransposition
US Patent:
2013031, Nov 28, 2013
Filed:
Aug 4, 2010
Appl. No.:
13/883962
Inventors:
Fred H. Gage - La Jolla CA, US
Nicole Coufal - San Diego CA, US
Michael J. McConnell - Charlottesville VA, US
Alysson Muotri - La Jolla CA, US
Maria C.N. Marchetto - La Jolla CA, US
Nicole Coufal - San Diego CA, US
Michael J. McConnell - Charlottesville VA, US
Alysson Muotri - La Jolla CA, US
Maria C.N. Marchetto - La Jolla CA, US
Assignee:
Salk Institute for Biological Studies - La Jolla CA
International Classification:
C12Q 1/68
US Classification:
424 941, 506 9, 435375, 435368, 435 611
Abstract:
A method of treating increased non-LTR retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-LTR retrotransposition in the neural cell or a progeny of the neural cell. In various embodiments, the non-LTR retrotransposition involves at least one L1 retrotransposon. Also provided is a method of assaying retrotransposition in neural cells. The method includes sorting synchronized neural cells of the same genetic background into single neural cells, and subjecting one or more of the sorted single neural cells to quantitative polymerase chain reaction amplification of at least one retrotransposon. In addition, a method of identifying an inhibitor of retrotransposition and a identifying a neural condition associated with non-LTR retrotransposition are provided.
Retroelements And Mental Disorders And Methods Of Measuring L1 Retrotransposition
Retroelements And Mental Disorders And Methods Of Measuring L1 Retrotransposition
US Patent:
2014003, Feb 6, 2014
Filed:
Feb 3, 2012
Appl. No.:
13/388982
Inventors:
Fred H. Gage - La Jolla CA, US
Nicole Coufal - San Diego CA, US
Mike McConnell - Del Mar CA, US
Alysson Muotri - La Jolla CA, US
Maria C.N. Marchetto - La Jolla CA, US
Nicole Coufal - San Diego CA, US
Mike McConnell - Del Mar CA, US
Alysson Muotri - La Jolla CA, US
Maria C.N. Marchetto - La Jolla CA, US
Assignee:
Salk Institute for Biological Studies - La Jolla CA
International Classification:
C12Q 1/68
US Classification:
514 177, 435375, 435368, 435184, 435 612
Abstract:
A method of treating increased non-LTR retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-LTR retrotransposition in the neural cell or a progeny of the neural cell. In various embodiments, the non-LTR retrotransposition involves at least one L1 retrotransposon. Also provided is a method of assaying retrotransposition in neural cells. The method includes sorting synchronized neural cells of the same genetic background into single neural cells, and subjecting one or more of the sorted single neural cells to quantitative polymerase chain reaction amplification of at least one retrotransposon. In addition, a method of identifying an inhibitor of retrotransposition and a identifying a neural condition associated with non-LTR retrotransposition are provided.