Methods And Compositions For Regulating Proliferation And Migration Of Vascular Smooth Muscle Cells
US Patent:
2009011, May 7, 2009
Filed:
Apr 25, 2008
Appl. No.:
12/150176
Inventors:
Nicholas E.S. Sibinga - Chappaqua NY, US Rong Hou - Fenton MO, US
International Classification:
A61K 9/00, C07K 14/705, C12N 15/63
US Classification:
424423, 530350, 4353201
Abstract:
Provided is an extracellular domain of a mammalian Fat1 (Fat1). Also provided is an intracellular domain of a mammalian Fat1 (Fat1). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1. A vector comprising a nucleic acid sequence encoding the Fat1is further provided. Also, a vascular stent coated with the Fat1is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.