NICHOLAS ROBERT BACHUR, JR
Pilots at Monkton Rd, Hereford, MD

6372485, Apr 16, 2002

May 17, 2000

09/572078

Alexander W. Clark - Baltimore MD
Paul Gladnick - Seattle WA
Robert E. Armstrong - Hunt Vally MD
Nicholas Bachur - Monkton MD
Klaus W. Berndt - Timonium MD
Dwight Livingston - Fallston MD

Becton Dickinson and Company - Franklin Lakes NJ

C12M 134

4352887, 4352874, 435808, 422 8205, 356317, 356432, 356213

A diagnostic microbiological testing system and method for microorganism identification (ID) and antimicrobial susceptibility determinations (AST). The system includes multiple-well test panels capable of performing ID and AST testing on the same test panel. Each test panel is inoculated with reagents, broth-suspended organisms, and placed into the instrument system. The instrument system includes a rotating carousel for incubation and indexing, multiple light sources each emitting different wavelength light, precision calorimetric and fluorometric detection, barcode test panel tracking and a control processor for making determinations based on measured test data. One light source includes a plurality of LEDs arranged in a linear array. Each of the LEDs junction currents are controllable to produce a predetermined illumination profile.

2002019, Dec 26, 2002

Jun 26, 2001

09/892012

Nicholas Bachur - Monkton MD, US

C12M001/34

435/287500, 435/288700

A system and method for monitoring the concentration of a medium in at least one container using photothermal spectroscopy. The medium can be a gas, such as oxygen or carbon dioxide, or a solid or liquid. The system and method each employs an energy emitting device, such as a laser or any other suitable type of light emitting device, which is adapted to emit a first energy signal toward a location in the container. The first energy signal has a wavelength that is substantially equal to a wavelength at which the medium absorbs the first energy signal so that absorption of the first energy signal changes a refractive index of a portion of the medium. The system and method each also employs a second energy emitting device, adapted to emit a second energy signal toward the portion of the medium while the refractive index of the portion is changed by the first energy signal, and a detector, adapted to detect a portion of the second energy signal that passes through the portion of the medium. The system and method each further employs a signal analyzer, adapted to analyze the detected portion of the second energy signal to determine an amount of a sample in the container based on a concentration of the medium in the container. In particular, the signal analyzer can analyze the detection portion of the second energy signal to determine whether the sample includes an organism which consumes or emits the medium.

7115384, Oct 3, 2006

Jan 28, 2002

10/056028

Alexander W. Clark - Baltimore MD, US
Paul Gladnick - Seattle WA, US
Robert E. Armstrong - Hunt Vally MD, US
Nicholas Bachur - Monkton MD, US
Klaus W. Berndt - Timonium MD, US
Dwight Livingston - Fallston MD, US

Becton Dickinson and Company - Franklin Lakes NJ

C12Q 1/02

435 29, 435 31, 4352862, 4352873, 4352887, 422 64

A diagnostic microbiological testing system and method for microorganism identification (ID) and antimicrobial susceptibility determinations (AST). The system includes multiple-well test panels capable of performing ID and AST testing on the same test panel. Each test panel is inoculated with reagents, broth-suspended organisms, and placed into the instrument system. The instrument system includes a rotating carousel for incubation and indexing, multiple light sources each emitting different wavelength light, precision calorimetric and fluorometric detection, barcode test panel tracking and a control processor for making determinations based on measured test data. One light source includes a plurality of LEDs arranged in a linear array. Each of the LEDs' junction currents are controllable to produce a predetermined illumination profile.

2007018, Aug 9, 2007

Dec 28, 2006

11/647688

Richard M. Ivey - Parkton MD, US
Thomas M. Gentle - Red Lion PA, US
Richard L. Moore - Glenville PA, US
Michael L. Towns - Timonium MD, US
Nicholas Bachur - Monkton MD, US
Robert W. Rosenstein - Ellicott City MD, US
James G. Nadeau - Ellicott City MD, US
Paul E. Goldenbaum - Hampstead MD, US
Song Shi - Reisterstown MD, US
Donald Copertino - Catonsville MD, US
James Garrett - Baltimore MD, US
Gregory Tice - Lutherville MD, US
Gary Siuzdak - San Diego CA, US
Elizabeth Want - San Diego CA, US
Zhouxin Shen - San Diego CA, US

Becton, Dickinson and Company - Franklin Lakes NJ

C12Q 1/37, G06F 19/00

435 23, 702 19

Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.

2004009, May 20, 2004

Nov 12, 2003

10/704661

Richard Ivey - Parkton MD, US
Thomas Gentle - Red Lion PA, US
Richard Moore - Glenville PA, US
Michael Towns - Timonium MD, US
Nicholas Bachur - Monkton MD, US
Robert Rosenstein - Ellicott City MD, US
Paul Goldenbaum - Hampstead MD, US
Song Shi - Reisterstown MD, US
Donald Copertino - Catonsville MD, US
James Garrett - Baltimore MD, US
Gregory Tice - Lutherville MD, US

Becton, Dickinson and Company - Franklin Lakes NJ

A61K048/00, C12Q001/68

514/044000, 435/006000

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

2004009, May 20, 2004

Nov 12, 2003

10/704899

Richard Ivey - Parkton MD, US
Thomas Gentle - Red Lion PA, US
Richard Moore - Glenville PA, US
Michael Towns - Timonium MD, US
Nicholas Bachur - Monkton MD, US
Robert Rosenstein - Ellicott City MD, US
James Nadeau - Ellicott City MD, US
Paul Goldenbaum - Hampstead MD, US
Song Shi - Reisterstown MD, US
Donald Copertino - Catonsville MD, US
James Garrett - Baltimore MD, US
Gregory Tice - Lutherville MD, US

Becton, Dickinson and Company - Franklin Lakes NJ

G01N033/554, G01N033/569

435/007320

The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

2006015, Jul 13, 2006

Nov 8, 2005

11/269100

Nicholas Bachur - Monkton MD, US
Timothy Foley - Fallston MD, US

Becton, Dickinson and Company - Franklin lakes NJ

G06F 19/00, C12Q 1/04, C12M 1/34

435034000, 702019000, 435287100

A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results to account for the out-of-specification sample.

2006016, Jul 20, 2006

Dec 22, 2005

11/315612

Nicholas Bachur - Monkton MD, US
John Neubert - Westminster MD, US

Becton, Dickinson and Company - Franklin Lakes NJ

C12Q 1/04

435034000, 204450000

A system and method is provided for non-invasively measuring changes in a specimen suspected of containing one or more microbes, by monitoring changes in the dielectric constant of the specimen caused by metabolic processes of such microbes.

2007001, Jan 25, 2007

Mar 28, 2006

11/391981

Timothy Foley - Forest Hill MD, US
P. Beaty - Dallastown PA, US
Michael Walters - Baltimore MD, US
Alexander Clark - Baltimore MD, US
Dwight Livingston - Fallston MD, US
A. Lentz - York PA, US
Miroslaw Bartkowiak - New Freedom PA, US
Daniel Schwartz - Timonium MD, US
Nicholas Bachur - Monkton MD, US

Becton, Dickinson and Company - Franklin Lakes NJ

B01F 13/08

366273000

A system comprising one or more sample vessels is provided, the sample vessels comprising a liquid growth medium and a stirrer element, the stirrer element capable of being influenced by a magnetic force, and an incubation and measurement module comprising one or more openings for holding the one or more sample vessels. The incubation and measurement module further comprises at least two drive magnets associated with each of the sample vessels, and a magnet driver adapted to repeatedly move each of the at least two drive magnets toward and away from the surface of the associated sample vessel.

2007029, Dec 27, 2007

Jun 23, 2006

11/426032

Nicholas R. Bachur - Monkton MD, US
Paul Goldenbaum - Dayton NV, US
Robert Rosenstein - Ellicott City MD, US
Timothy Hansen - Spring Grove PA, US

Becton, Dickinson and Company - Franklin Lakes NJ

C12M 3/00

4352872, 600315

An assay transponder is disclosed. The assay transponder has an RF transceiver that allows the assay transponder to communicate wirelessly with another RF device. The transponder also has a sensor that interrogates an assay associated with the transponder. The assay exhibits a response to a sample environment in which the transponder is placed. The transponder communicates the results of the assay interrogation to the other RF device by modulating a signal indicative of the results onto an RF carrier signal and transmitting the signal via an antenna.